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10.3390/cells10030628 http://scihub22266oqcxt.onion/10.3390/cells10030628 33808998!8001029!33808998     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2021 ; 10 (3): ä Nephropedia Template TP {{tp|p=33808998|t=2021. Thymic Aging May Be Associated with COVID-19 Pathophysiology in the Elderly |pdf=|usr=}}{{33808998}} gab.com Text Thymic Aging May Be Associated with COVID-19 Pathophysiology in the Elderly JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=33808998 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the global pandemic of coronavirus disease 2019 (COVID-19) and particularly exhibits severe symptoms and mortality in elderly individuals. Mounting evidence shows that the characteristics of the age-related clinical severity of COVID-19 are attributed to insufficient antiviral immune function and excessive self-damaging immune reaction, involving T cell immunity and associated with pre-existing basal inflammation in the elderly. Age-related changes to T cell immunosenescence is characterized by not only restricted T cell receptor (TCR) repertoire diversity, accumulation of exhausted and/or senescent memory T cells, but also by increased self-reactive T cell- and innate immune cell-induced chronic inflammation, and accumulated and functionally enhanced polyclonal regulatory T (Treg) cells. Many of these changes can be traced back to age-related thymic involution/degeneration. How these changes contribute to differences in COVID-19 disease severity between young and aged patients is an urgent area of investigation. Therefore, we attempt to connect various clues in this field by reviewing and discussing recent research on the role of the thymus and T cells in COVID-19 immunity during aging (a synergistic effect of diminished responses to pathogens and enhanced responses to self) impacting age-related clinical severity of COVID-19. We also address potential combinational strategies to rejuvenate multiple aging-impacted immune system checkpoints by revival of aged thymic function, boosting peripheral T cell responses, and alleviating chronic, basal inflammation to improve the efficiency of anti-SARS-CoV-2 immunity and vaccination in the elderly. Twit Text FOAVip Thymic Aging May Be Associated with COVID-19 Pathophysiology in the Elderly ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=33808998 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33808998 #FOAvip English Wikipedia <ref>{{Cite pmid|33808998}}</ref> Thymic Aging May Be Associated with COVID-19 Pathophysiology in the Elderly #MMPMID33808998 Wang W; Thomas R; Oh J; Su DM Cells 2021[Mar]; 10 (3): ä PMID33808998show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the global pandemic of coronavirus disease 2019 (COVID-19) and particularly exhibits severe symptoms and mortality in elderly individuals. Mounting evidence shows that the characteristics of the age-related clinical severity of COVID-19 are attributed to insufficient antiviral immune function and excessive self-damaging immune reaction, involving T cell immunity and associated with pre-existing basal inflammation in the elderly. Age-related changes to T cell immunosenescence is characterized by not only restricted T cell receptor (TCR) repertoire diversity, accumulation of exhausted and/or senescent memory T cells, but also by increased self-reactive T cell- and innate immune cell-induced chronic inflammation, and accumulated and functionally enhanced polyclonal regulatory T (Treg) cells. Many of these changes can be traced back to age-related thymic involution/degeneration. How these changes contribute to differences in COVID-19 disease severity between young and aged patients is an urgent area of investigation. Therefore, we attempt to connect various clues in this field by reviewing and discussing recent research on the role of the thymus and T cells in COVID-19 immunity during aging (a synergistic effect of diminished responses to pathogens and enhanced responses to self) impacting age-related clinical severity of COVID-19. We also address potential combinational strategies to rejuvenate multiple aging-impacted immune system checkpoints by revival of aged thymic function, boosting peripheral T cell responses, and alleviating chronic, basal inflammation to improve the efficiency of anti-SARS-CoV-2 immunity and vaccination in the elderly. |Aged[MESH] |Aged, 80 and over[MESH] |Aging/immunology/pathology[MESH] |Autoimmunity[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*immunology/physiopathology[MESH] |Cellular Senescence/*immunology[MESH] |Humans[MESH] |Inflammation/immunology/pathology[MESH] |SARS-CoV-2/immunology[MESH] |T-Lymphocytes/*immunology[MESH]Thymic Aging May Be Associated with COVID-19 Pathophysiology in the El(epmc).pdf DeepDyve Pubget Overpricing