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10.3390/molecules26071977 http://scihub22266oqcxt.onion/10.3390/molecules26071977 33807474!8037657!33807474     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Molecules 2021 ; 26 (7): ä Nephropedia Template TP {{tp|p=33807474|t=2021. Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study |pdf=|usr=}}{{33807474}} gab.com Text Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33807474 #FOAvip Protein kinases are a large class of enzymes with numerous biological roles and many have been implicated in a vast array of diseases, including cancer and the novel coronavirus infection COVID-19. Thus, the development of chemical probes to selectively target each kinase is of great interest. Inhibition of protein kinases with ATP-competitive inhibitors has historically been the most widely used method. However, due to the highly conserved structures of ATP-sites, the identification of truly selective chemical probes is challenging. In this review, we use the Ser/Thr kinase CK2 as an example to highlight the historical challenges in effective and selective chemical probe development, alongside recent advances in the field and alternative strategies aiming to overcome these problems. The methods utilised for CK2 can be applied to an array of protein kinases to aid in the discovery of chemical probes to further understand each kinase's biology, with wide-reaching implications for drug development. Twit Text FOAVip Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33807474 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33807474 #FOAvip English Wikipedia <ref>{{Cite pmid|33807474}}</ref> Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study #MMPMID33807474 Atkinson EL; Iegre J; Brear PD; Zhabina EA; Hyvonen M; Spring DR Molecules 2021[Mar]; 26 (7): ä PMID33807474show ga Protein kinases are a large class of enzymes with numerous biological roles and many have been implicated in a vast array of diseases, including cancer and the novel coronavirus infection COVID-19. Thus, the development of chemical probes to selectively target each kinase is of great interest. Inhibition of protein kinases with ATP-competitive inhibitors has historically been the most widely used method. However, due to the highly conserved structures of ATP-sites, the identification of truly selective chemical probes is challenging. In this review, we use the Ser/Thr kinase CK2 as an example to highlight the historical challenges in effective and selective chemical probe development, alongside recent advances in the field and alternative strategies aiming to overcome these problems. The methods utilised for CK2 can be applied to an array of protein kinases to aid in the discovery of chemical probes to further understand each kinase's biology, with wide-reaching implications for drug development. |Adenosine Triphosphate/metabolism[MESH] |Binding Sites[MESH] |COVID-19[MESH] |Casein Kinase II/chemistry/*metabolism[MESH] |Dichlororibofuranosylbenzimidazole/chemistry/pharmacology[MESH] |Humans[MESH] |Molecular Probes/*chemistry/metabolism[MESH] |Naphthyridines/chemistry/pharmacology[MESH] |Phenazines/chemistry/pharmacology[MESH] |Polyphenols/chemistry/pharmacology[MESH] |Protein Kinase Inhibitors/*chemistry/pharmacology[MESH]Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a C(epmc).pdf DeepDyve Pubget Overpricing