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10.3390/cells10030708 http://scihub22266oqcxt.onion/10.3390/cells10030708 33806810!8004738!33806810     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cells 2021 ; 10 (3): ä Nephropedia Template TP {{tp|p=33806810|t=2021. Aging and Interferons: Impacts on Inflammation and Viral Disease Outcomes |pdf=|usr=}}{{33806810}} gab.com Text Aging and Interferons: Impacts on Inflammation and Viral Disease Outcomes JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=33806810 #FOAvip As highlighted by the COVID-19 global pandemic, elderly individuals comprise the majority of cases of severe viral infection outcomes and death. A combined inability to control viral replication and exacerbated inflammatory immune activation in elderly patients causes irreparable immune-mediated tissue pathology in response to infection. Key to these responses are type I, II, and III interferons (IFNs), which are involved in inducing an antiviral response, as well as controlling and suppressing inflammation and immunopathology. IFNs support monocyte/macrophage-stimulated immune responses that clear infection and promote their immunosuppressive functions that prevent excess inflammation and immune-mediated pathology. The timing and magnitude of IFN responses to infection are critical towards their immunoregulatory functions and ability to prevent immunopathology. Aging is associated with multiple defects in the ability of macrophages and dendritic cells to produce IFNs in response to viral infection, leading to a dysregulation of inflammatory immune responses. Understanding the implications of aging on IFN-regulated inflammation will give critical insights on how to treat and prevent severe infection in vulnerable individuals. In this review, we describe the causes of impaired IFN production in aging, and the evidence to suggest that these impairments impact the regulation of the innate and adaptive immune response to infection, thereby causing disease pathology. Twit Text FOAVip Aging and Interferons: Impacts on Inflammation and Viral Disease Outcomes ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=33806810 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33806810 #FOAvip English Wikipedia <ref>{{Cite pmid|33806810}}</ref> Aging and Interferons: Impacts on Inflammation and Viral Disease Outcomes #MMPMID33806810 Feng E; Balint E; Poznanski SM; Ashkar AA; Loeb M Cells 2021[Mar]; 10 (3): ä PMID33806810show ga As highlighted by the COVID-19 global pandemic, elderly individuals comprise the majority of cases of severe viral infection outcomes and death. A combined inability to control viral replication and exacerbated inflammatory immune activation in elderly patients causes irreparable immune-mediated tissue pathology in response to infection. Key to these responses are type I, II, and III interferons (IFNs), which are involved in inducing an antiviral response, as well as controlling and suppressing inflammation and immunopathology. IFNs support monocyte/macrophage-stimulated immune responses that clear infection and promote their immunosuppressive functions that prevent excess inflammation and immune-mediated pathology. The timing and magnitude of IFN responses to infection are critical towards their immunoregulatory functions and ability to prevent immunopathology. Aging is associated with multiple defects in the ability of macrophages and dendritic cells to produce IFNs in response to viral infection, leading to a dysregulation of inflammatory immune responses. Understanding the implications of aging on IFN-regulated inflammation will give critical insights on how to treat and prevent severe infection in vulnerable individuals. In this review, we describe the causes of impaired IFN production in aging, and the evidence to suggest that these impairments impact the regulation of the innate and adaptive immune response to infection, thereby causing disease pathology. |*Adaptive Immunity[MESH] |*Immunity, Innate[MESH] |Aged[MESH] |Aging/*immunology[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/*immunology/virology[MESH] |Humans[MESH] |Inflammation/drug therapy/immunology[MESH] |Interferon Lambda[MESH] |Interferon Type I/immunology/therapeutic use[MESH] |Interferon-gamma/immunology/therapeutic use[MESH] |Interferons/immunology/*physiology/therapeutic use[MESH] |SARS-CoV-2/*immunology[MESH]Aging and Interferons: Impacts on Inflammation and Viral Disease Outco(epmc).pdf DeepDyve Pubget Overpricing