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10.3390/ijms22052549 http://scihub22266oqcxt.onion/10.3390/ijms22052549 33806292!7961517!33806292     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (5): ä Nephropedia Template TP {{tp|p=33806292|t=2021. Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress |pdf=|usr=}}{{33806292}} gab.com Text Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33806292 #FOAvip Mitochondria are the largest source of reactive oxygen species (ROS) and are intracellular organelles that produce large amounts of the most potent hydroxyl radical (.OH). Molecular hydrogen (H(2)) can selectively eliminate .OH generated inside of the mitochondria. Inflammation is induced by the release of proinflammatory cytokines produced by macrophages and neutrophils. However, an uncontrolled or exaggerated response often occurs, resulting in severe inflammation that can lead to acute or chronic inflammatory diseases. Recent studies have reported that ROS activate NLRP3 inflammasomes, and that this stimulation triggers the production of proinflammatory cytokines. It has been shown in literature that H(2) can be based on the mechanisms that inhibit mitochondrial ROS. However, the ability for H(2) to inhibit NLRP3 inflammasome activation via mitochondrial oxidation is poorly understood. In this review, we hypothesize a possible mechanism by which H(2) inhibits mitochondrial oxidation. Medical applications of H(2) may solve the problem of many chronic inflammation-based diseases, including coronavirus disease 2019 (COVID-19). Twit Text FOAVip Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33806292 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33806292 #FOAvip English Wikipedia <ref>{{Cite pmid|33806292}}</ref> Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory Diseases: Possible Inhibiting Role on Mitochondrial Stress #MMPMID33806292 Hirano SI; Ichikawa Y; Sato B; Yamamoto H; Takefuji Y; Satoh F Int J Mol Sci 2021[Mar]; 22 (5): ä PMID33806292show ga Mitochondria are the largest source of reactive oxygen species (ROS) and are intracellular organelles that produce large amounts of the most potent hydroxyl radical (.OH). Molecular hydrogen (H(2)) can selectively eliminate .OH generated inside of the mitochondria. Inflammation is induced by the release of proinflammatory cytokines produced by macrophages and neutrophils. However, an uncontrolled or exaggerated response often occurs, resulting in severe inflammation that can lead to acute or chronic inflammatory diseases. Recent studies have reported that ROS activate NLRP3 inflammasomes, and that this stimulation triggers the production of proinflammatory cytokines. It has been shown in literature that H(2) can be based on the mechanisms that inhibit mitochondrial ROS. However, the ability for H(2) to inhibit NLRP3 inflammasome activation via mitochondrial oxidation is poorly understood. In this review, we hypothesize a possible mechanism by which H(2) inhibits mitochondrial oxidation. Medical applications of H(2) may solve the problem of many chronic inflammation-based diseases, including coronavirus disease 2019 (COVID-19). |Animals[MESH] |COVID-19/*therapy[MESH] |Chronic Disease[MESH] |Humans[MESH] |Hydrogen/*pharmacology/*therapeutic use[MESH] |Inflammation/metabolism/*therapy[MESH] |Mitochondria/*physiology[MESH] |NLR Family, Pyrin Domain-Containing 3 Protein/antagonists & inhibitors/metabolism[MESH]Potential Therapeutic Applications of Hydrogen in Chronic Inflammatory(epmc).pdf DeepDyve Pubget Overpricing