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10.3390/diagnostics11040593

http://scihub22266oqcxt.onion/10.3390/diagnostics11040593
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suck abstract from ncbi


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pmid33806216      Diagnostics+(Basel) 2021 ; 11 (4): ä
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  • Five Commercial Immunoassays for SARS-CoV-2 Antibody Determination and Their Comparison and Correlation with the Virus Neutralization Test #MMPMID33806216
  • Simanek V; Pecen L; Kratka Z; Furst T; Rezackova H; Topolcan O; Fajfrlik K; Sedlacek D; Sin R; Pazdiora P; Zelena H; Slouka D; Kucera R
  • Diagnostics (Basel) 2021[Mar]; 11 (4): ä PMID33806216show ga
  • There is an ongoing debate as to whether SARS-CoV-2 antibodies can be found in patients who have recovered from COVID-19 disease. Currently, there is no consensus on whether the antibodies, if present, are protective. Our regular measurements of SARS-CoV-2 antibodies, starting in July 2020, have provided us with the opportunity of becoming acquainted with the five different immunoassays. A total of 149 patients were enrolled in our study. We measured the samples using each immunoassay, then performing a virus neutralization test and comparing the results of SARS-CoV-2 antibodies with this test. We observed that the production of neutralizing antibodies is age-dependent. Elderly patients have a higher proportion of high neutralizing titers than young patients. Based on our results, and in combination with the literature findings, we can conclude that the serological SARS-CoV-2 antibody measurement is a helpful tool in the fight against COVID-19. The assays can provide information about the patient's previous contact with the virus. Anti-spike protein assays correlate well with the virus neutralization test and can be used in the screening of potential convalescent plasma donors.
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