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10.3390/ijms22062921

http://scihub22266oqcxt.onion/10.3390/ijms22062921
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33805739!7998619!33805739
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suck abstract from ncbi


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pmid33805739      Int+J+Mol+Sci 2021 ; 22 (6): ä
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  • Placental Immune Responses to Viruses: Molecular and Histo-Pathologic Perspectives #MMPMID33805739
  • Narang K; Cheek EH; Enninga EAL; Theiler RN
  • Int J Mol Sci 2021[Mar]; 22 (6): ä PMID33805739show ga
  • As most recently demonstrated by the SARS-CoV-2 pandemic, congenital and perinatal infections are of significant concern to the pregnant population as compared to the general population. These outcomes can range from no apparent impact all the way to spontaneous abortion or fetal infection with long term developmental consequences. While some pathogens have developed mechanisms to cross the placenta and directly infect the fetus, other pathogens lead to an upregulation in maternal or placental inflammation that can indirectly cause harm. The placenta is a temporary, yet critical organ that serves multiple important functions during gestation including facilitation of fetal nutrition, oxygenation, and prevention of fetal infection in utero. Here, we review trophoblast cell immunology and the molecular mechanisms utilized to protect the fetus from infection. Lastly, we discuss consequences in the placenta when these protections fail and the histopathologic result following infection.
  • |*Immunity[MESH]
  • |Female[MESH]
  • |Fetus/immunology/virology[MESH]
  • |Humans[MESH]
  • |Placenta/*immunology/pathology/*virology[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Complications, Infectious/*immunology/*virology[MESH]
  • |Trophoblasts/immunology/virology[MESH]
  • |Virus Diseases/*immunology[MESH]


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