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10.3390/v13040538 http://scihub22266oqcxt.onion/10.3390/v13040538 33804957!8063928!33804957     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (4): ä Nephropedia Template TP {{tp|p=33804957|t=2021. NSP16 2 -O-MTase in Coronavirus Pathogenesis: Possible Prevention and Treatments Strategies |pdf=|usr=}}{{33804957}} gab.com Text NSP16 2 -O-MTase in Coronavirus Pathogenesis: Possible Prevention and Treatments Strategies JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33804957 #FOAvip Several life-threatening viruses have recently appeared, including the coronavirus, infecting a variety of human and animal hosts and causing a range of diseases like human upper respiratory tract infections. They not only cause serious human and animal deaths, but also cause serious public health problems worldwide. Currently, seven species are known to infect humans, namely SARS-CoV-2, MERS-CoV, SARS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1. The coronavirus nonstructural protein 16 (NSP16) structure is similar to the 5'-end capping system of mRNA used by eukaryotic hosts and plays a vital role in evading host immunity response and protects the nascent viral mRNA from degradation. NSP16 is also well-conserved among related coronaviruses and requires its binding partner NSP10 to activate its enzymatic activity. With the continued threat of viral emergence highlighted by human coronaviruses and SARS-CoV-2, mutant strains continue to appear, affecting the highly conserved NSP16: this provides a possible therapeutic approach applicable to any novel coronavirus. To this end, current information on the 2'-O-MTase activity mechanism, the differences between NSP16 and NSP10 in human coronaviruses, and the current potential prevention and treatment strategies related to NSP16 are summarized in this review. Twit Text FOAVip NSP16 2 -O-MTase in Coronavirus Pathogenesis: Possible Prevention and Treatments Strategies ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33804957 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33804957 #FOAvip English Wikipedia <ref>{{Cite pmid|33804957}}</ref> NSP16 2 -O-MTase in Coronavirus Pathogenesis: Possible Prevention and Treatments Strategies #MMPMID33804957 Chang LJ; Chen TH Viruses 2021[Mar]; 13 (4): ä PMID33804957show ga Several life-threatening viruses have recently appeared, including the coronavirus, infecting a variety of human and animal hosts and causing a range of diseases like human upper respiratory tract infections. They not only cause serious human and animal deaths, but also cause serious public health problems worldwide. Currently, seven species are known to infect humans, namely SARS-CoV-2, MERS-CoV, SARS-CoV, HCoV-229E, HCoV-NL63, HCoV-OC43, and HCoV-HKU1. The coronavirus nonstructural protein 16 (NSP16) structure is similar to the 5'-end capping system of mRNA used by eukaryotic hosts and plays a vital role in evading host immunity response and protects the nascent viral mRNA from degradation. NSP16 is also well-conserved among related coronaviruses and requires its binding partner NSP10 to activate its enzymatic activity. With the continued threat of viral emergence highlighted by human coronaviruses and SARS-CoV-2, mutant strains continue to appear, affecting the highly conserved NSP16: this provides a possible therapeutic approach applicable to any novel coronavirus. To this end, current information on the 2'-O-MTase activity mechanism, the differences between NSP16 and NSP10 in human coronaviruses, and the current potential prevention and treatment strategies related to NSP16 are summarized in this review. |Animals[MESH] |COVID-19/virology[MESH] |Coronavirus Infections/*virology[MESH] |Coronavirus/enzymology/genetics/*metabolism[MESH] |Humans[MESH] |Methyltransferases/genetics/*metabolism[MESH] |SARS-CoV-2/enzymology/genetics/metabolism[MESH]NSP16 2 -O-MTase in Coronavirus Pathogenesis: Possible Prevention and (epmc).pdf DeepDyve Pubget Overpricing