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10.3390/ijms22063184 http://scihub22266oqcxt.onion/10.3390/ijms22063184 33804769!8003878!33804769     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2021 ; 22 (6): ä Nephropedia Template TP {{tp|p=33804769|t=2021. Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-beta in Triggering Inflammatory Signals in Cells of Distant Organ |pdf=|usr=}}{{33804769}} gab.com Text Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-beta in Triggering Inflammatory Signals in Cells of Distant Organ JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33804769 #FOAvip SARS-CoV-2 infection can cause cytokine storm and may overshoot immunity in humans; however, it remains to be determined whether virus-induced soluble mediators from infected cells are carried by exosomes as vehicles to distant organs and cause tissue damage in COVID-19 patients. We took an unbiased proteomic approach for analyses of exosomes isolated from plasma of healthy volunteers and COVID-19 patients. Our results revealed that tenascin-C (TNC) and fibrinogen-beta (FGB) are highly abundant in exosomes from COVID-19 patients' plasma compared with that of healthy normal controls. Since TNC and FGB stimulate pro-inflammatory cytokines via the Nuclear factor-kappaB (NF-kappaB) pathway, we examined the status of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and C-C motif chemokine ligand 5 (CCL5) expression upon exposure of hepatocytes to exosomes from COVID-19 patients and observed significant increase compared with that from healthy subjects. Together, our results demonstrate that TNC and FGB are transported through plasma exosomes and potentially trigger pro-inflammatory cytokine signaling in cells of distant organ. Twit Text FOAVip Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-beta in Triggering Inflammatory Signals in Cells of Distant Organ ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33804769 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33804769 #FOAvip English Wikipedia <ref>{{Cite pmid|33804769}}</ref> Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-beta in Triggering Inflammatory Signals in Cells of Distant Organ #MMPMID33804769 Sur S; Khatun M; Steele R; Isbell TS; Ray R; Ray RB Int J Mol Sci 2021[Mar]; 22 (6): ä PMID33804769show ga SARS-CoV-2 infection can cause cytokine storm and may overshoot immunity in humans; however, it remains to be determined whether virus-induced soluble mediators from infected cells are carried by exosomes as vehicles to distant organs and cause tissue damage in COVID-19 patients. We took an unbiased proteomic approach for analyses of exosomes isolated from plasma of healthy volunteers and COVID-19 patients. Our results revealed that tenascin-C (TNC) and fibrinogen-beta (FGB) are highly abundant in exosomes from COVID-19 patients' plasma compared with that of healthy normal controls. Since TNC and FGB stimulate pro-inflammatory cytokines via the Nuclear factor-kappaB (NF-kappaB) pathway, we examined the status of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and C-C motif chemokine ligand 5 (CCL5) expression upon exposure of hepatocytes to exosomes from COVID-19 patients and observed significant increase compared with that from healthy subjects. Together, our results demonstrate that TNC and FGB are transported through plasma exosomes and potentially trigger pro-inflammatory cytokine signaling in cells of distant organ. |Aged[MESH] |COVID-19/*blood/complications[MESH] |Cell Line[MESH] |Chemokine CCL5/metabolism[MESH] |Exosomes/*chemistry/*genetics/metabolism/ultrastructure[MESH] |Female[MESH] |Fibrinogen/*metabolism[MESH] |Hepatocytes/metabolism[MESH] |Humans[MESH] |Inflammation/etiology/*metabolism[MESH] |Interleukin-6/metabolism[MESH] |Male[MESH] |Mass Spectrometry[MESH] |Microscopy, Electron, Transmission[MESH] |Middle Aged[MESH] |NF-kappa B/metabolism[MESH] |Protein Interaction Maps[MESH] |Proteome/metabolism[MESH] |Tenascin/*metabolism[MESH]Exosomes from COVID-19 Patients Carry Tenascin-C and Fibrinogen-beta i(epmc).pdf DeepDyve Pubget Overpricing