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10.3390/jcm10061288

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suck abstract from ncbi


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pmid33804762      J+Clin+Med 2021 ; 10 (6): ä
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  • Lung Ultrasound Patterns and Clinical-Laboratory Correlates during COVID-19 Pneumonia: A Retrospective Study from North East Italy #MMPMID33804762
  • Senter R; Capone F; Pasqualin S; Cerruti L; Molinari L; Fonte Basso E; Zanforlin N; Previato L; Toffolon A; Sensi C; Arcidiacono G; Gorgi D; Ippolito R; Nessi E; Pettenella P; Cellini A; Fossa C; Vania E; Gardin S; Sukthi A; Luise D; Giordani MT; Zanatta M; Savino S; Cianci V; Sattin A; Maria A; Vianello A; Pesavento R; Giannini S; Avogaro A; Vettor R; Fadini GP; Saller A
  • J Clin Med 2021[Mar]; 10 (6): ä PMID33804762show ga
  • BACKGROUND AND AIM: Lung ultrasound (LUS) is a convenient imaging modality in the setting of coronavirus disease-19 (COVID-19) because it is easily available, can be performed bedside and repeated over time. We herein examined LUS patterns in relation to disease severity and disease stage among patients with COVID-19 pneumonia. METHODS: We performed a retrospective case series analysis of patients with confirmed SARS-CoV-2 infection who were admitted to the hospital because of pneumonia. We recorded history, clinical parameters and medications. LUS was performed and scored in a standardized fashion by experienced operators, with evaluation of up to 12 lung fields, reporting especially on B-lines and consolidations. RESULTS: We included 96 patients, 58.3% men, with a mean age of 65.9 years. Patients with a high-risk quick COVID-19 severity index (qCSI) were older and had worse outcomes, especially for the need for high-flow oxygen. B-lines and consolidations were located mainly in the lower posterior lung fields. LUS patterns for B-lines and consolidations were significantly worse in all lung fields among patients with high versus low qCSI. B-lines and consolidations were worse in the intermediate disease stage, from day 7 to 13 after onset of symptoms. While consolidations correlated more with inflammatory biomarkers, B-lines correlated more with end-organ damage, including extrapulmonary involvement. CONCLUSIONS: LUS patterns provide a comprehensive evaluation of patients with COVID-19 pneumonia that correlated with severity and dynamically reflect disease stage. LUS patterns may reflect different pathophysiological processes related to inflammation or tissue damage; consolidations may represent a more specific sign of localized disease, whereas B-lines seem to be also dependent upon generalized illness due to SARS-CoV-2 infection.
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