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10.3390/v13030394 http://scihub22266oqcxt.onion/10.3390/v13030394 33801257!7999997!33801257     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Viruses 2021 ; 13 (3): ä Nephropedia Template TP {{tp|p=33801257|t=2021. The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense |pdf=|usr=}}{{33801257}} gab.com Text The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33801257 #FOAvip Understanding SARS-CoV-2 evolution is a fundamental effort in coping with the COVID-19 pandemic. The virus genomes have been broadly evolving due to the high number of infected hosts world-wide. Mutagenesis and selection are two inter-dependent mechanisms of virus diversification. However, which mechanisms contribute to the mutation profiles of SARS-CoV-2 remain under-explored. Here, we delineate the contribution of mutagenesis and selection to the genome diversity of SARS-CoV-2 isolates. We generated a comprehensive phylogenetic tree with representative genomes. Instead of counting mutations relative to the reference genome, we identified each mutation event at the nodes of the phylogenetic tree. With this approach, we obtained the mutation events that are independent of each other and generated the mutation profile of SARS-CoV-2 genomes. The results suggest that the heterogeneous mutation patterns are mainly reflections of host (i) antiviral mechanisms that are achieved through APOBEC, ADAR, and ZAP proteins, and (ii) probable adaptation against reactive oxygen species. Twit Text FOAVip The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=33801257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33801257 #FOAvip English Wikipedia <ref>{{Cite pmid|33801257}}</ref> The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense #MMPMID33801257 Azgari C; Kilinc Z; Turhan B; Circi D; Adebali O Viruses 2021[Mar]; 13 (3): ä PMID33801257show ga Understanding SARS-CoV-2 evolution is a fundamental effort in coping with the COVID-19 pandemic. The virus genomes have been broadly evolving due to the high number of infected hosts world-wide. Mutagenesis and selection are two inter-dependent mechanisms of virus diversification. However, which mechanisms contribute to the mutation profiles of SARS-CoV-2 remain under-explored. Here, we delineate the contribution of mutagenesis and selection to the genome diversity of SARS-CoV-2 isolates. We generated a comprehensive phylogenetic tree with representative genomes. Instead of counting mutations relative to the reference genome, we identified each mutation event at the nodes of the phylogenetic tree. With this approach, we obtained the mutation events that are independent of each other and generated the mutation profile of SARS-CoV-2 genomes. The results suggest that the heterogeneous mutation patterns are mainly reflections of host (i) antiviral mechanisms that are achieved through APOBEC, ADAR, and ZAP proteins, and (ii) probable adaptation against reactive oxygen species. |*Mutation[MESH] |Base Sequence[MESH] |COVID-19/genetics/*immunology/*virology[MESH] |Codon/genetics[MESH] |Evolution, Molecular[MESH] |Genome, Viral[MESH] |Humans[MESH] |Pandemics[MESH] |Phylogeny[MESH]The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Ant(epmc).pdf DeepDyve Pubget Overpricing