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10.3390/microorganisms9030546

http://scihub22266oqcxt.onion/10.3390/microorganisms9030546
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suck abstract from ncbi


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pmid33800807      Microorganisms 2021 ; 9 (3): ä
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  • Recovery of Innate Immune Cells and Persisting Alterations in Adaptive Immunity in the Peripheral Blood of Convalescent Plasma Donors at Eight Months Post SARS-CoV-2 Infection #MMPMID33800807
  • Kostopoulos IV; Orologas-Stavrou N; Rousakis P; Panteli C; Ntanasis-Stathopoulos I; Charitaki I; Korompoki E; Gavriatopoulou M; Kastritis E; Trougakos IP; Dimopoulos MA; Tsitsilonis OE; Terpos E
  • Microorganisms 2021[Mar]; 9 (3): ä PMID33800807show ga
  • Persisting alterations and unique immune signatures have been previously detected in the peripheral blood of convalescent plasma (CP) donors at approximately two months after initial SARS-CoV-2 infection. This article presents the results on the sequential analysis of 47 CP donors at a median time of eight months (range 7.5-8.5 months) post infection, as assessed by flow cytometry. Interestingly, our results show a significant variation of the relevant immune subset composition among CP donors. Regarding innate immunity, both non-classical monocytes, and CD11b- granulocytes had fully recovered at eight months post COVID-19 infection. Intermediate monocytes and natural killer (NK) cells had already been restored at the two-month evaluation and remained stable. Regarding adaptive immunity, the COVID-19-related skewed Th1 and Th2 cell polarization remained at the same levels as in two months. However, low levels of total B cells were detected even after eight months from infection. A persisting reduction of CD8+ Tregs and changes in the NKT cell compartment were also remarkable. CP donors present with a unique immune landscape at eight months post COVID-19 infection, which is characterized by the notable restoration of the components of innate immunity along with a persisting imprint of SARS-CoV-2 in cells of the adaptive immunity.
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