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10.1016/j.bios.2021.113165

http://scihub22266oqcxt.onion/10.1016/j.bios.2021.113165
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suck abstract from ncbi


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pmid33799060      Biosens+Bioelectron 2021 ; 183 (ä): 113165
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  • Presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during CoViD-19 infection #MMPMID33799060
  • Schasfoort RBM; van Weperen J; van Amsterdam M; Parisot J; Hendriks J; Koerselman M; Karperien M; Mentink A; Bennink M; Krabbe H; Terstappen LW; Mulder AHL
  • Biosens Bioelectron 2021[Jul]; 183 (ä): 113165 PMID33799060show ga
  • Surface Plasmon Resonance imaging (SPRi) was used to determine the presence and strength of binding of IgG, IgM and IgA against the Receptor Binding Domain (RBD) of SARS-CoV-2 in sera of 119 CoViD-19 patients. The SPRi assay measures the antibody isotype levels and the strength of binding to the RBD of ultimate 384 patient samples in one run. It turns out that during the course of the disease, the IgG levels and strength of binding increased while generally the IgM and IgA levels go down. Recovered patients all show high strength of binding of the IgG type to the RBD protein. The anti-RBD immunoglobulins SPRi assay provides additional insights in the immune status of patients recovering from CoViD-19 and this new method can furthermore be applied for the assessment of the quality of the immune reaction of healthy individuals to SARS-CoV-2 in vaccination programs.
  • |*Biosensing Techniques[MESH]
  • |*COVID-19[MESH]
  • |Antibodies, Viral[MESH]
  • |Humans[MESH]
  • |Immunoglobulin A[MESH]
  • |Immunoglobulin G[MESH]
  • |Immunoglobulin M[MESH]


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