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10.1111/ijcp.14166 http://scihub22266oqcxt.onion/10.1111/ijcp.14166 33797849!8250061!33797849     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Clin+Pract 2021 ; 75 (7): e14166 Nephropedia Template TP {{tp|p=33797849|t=2021. Detectable respiratory SARS-CoV-2 RNA is associated with low vitamin D levels and high social deprivation |pdf=|usr=}}{{33797849}} gab.com Text Detectable respiratory SARS-CoV-2 RNA is associated with low vitamin D levels and high social deprivation JO: Int J Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=33797849 #FOAvip BACKGROUND: Accumulating evidence links COVID-19 incidence and outcomes with vitamin D status. We investigated if an interaction existed between vitamin D levels and social deprivation in those with and without COVID-19 infection. METHODS: Upper or lower respiratory tract samples from 104 patients were tested for SARS-CoV-2 RNA in accordance with Public Health England criteria (January-May 2020) using RT-PCR. The latest serum total 25-hydroxyvitamin D(25-OHD) levels, quantified by LC-MS/MS, was obtained for each patient (September 2019-April 2020). Index of Multiple Deprivation (IMD) was generated for each patient. Univariate and logistic regression analyses examined associations between age, gender, 25-OHD, IMD score and SARS-CoV-2 result in the total cohort and subgroups. RESULTS: In the total cohort, a positive SARS-CoV-2 test was significantly associated with lower 25-OHD levels and higher IMD. A positive test was associated with higher IMD in the male subgroup and with lower 25-OHD levels in those aged >72 years. Low 25-OHD and IMD quintile 5 were separately associated with positive COVID-19 outcome in the cohort. Patients in IMD quintile 5 with vitamin D levels </= 34.4 nmol/L were most likely to have a positive COVID-19 outcome, even more so if aged >72 years (OR: 19.07, 95%CI: 1.71-212.25; P = .016). CONCLUSIONS: In this cohort, combined low vitamin D levels and higher social deprivation were most associated with COVID-19 infection. In older age, this combination was even more significant. Our data support the recommendations for normalising vitamin D levels in those with deficient / insufficient levels and in groups at high risk for deficiency. Twit Text FOAVip Detectable respiratory SARS-CoV-2 RNA is associated with low vitamin D levels and high social deprivation ????Int J Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=33797849 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33797849 #FOAvip English Wikipedia <ref>{{Cite pmid|33797849}}</ref> Detectable respiratory SARS-CoV-2 RNA is associated with low vitamin D levels and high social deprivation #MMPMID33797849 Livingston M; Plant A; Dunmore S; Hartland A; Jones S; Laing I; Ramachandran S Int J Clin Pract 2021[Jul]; 75 (7): e14166 PMID33797849show ga BACKGROUND: Accumulating evidence links COVID-19 incidence and outcomes with vitamin D status. We investigated if an interaction existed between vitamin D levels and social deprivation in those with and without COVID-19 infection. METHODS: Upper or lower respiratory tract samples from 104 patients were tested for SARS-CoV-2 RNA in accordance with Public Health England criteria (January-May 2020) using RT-PCR. The latest serum total 25-hydroxyvitamin D(25-OHD) levels, quantified by LC-MS/MS, was obtained for each patient (September 2019-April 2020). Index of Multiple Deprivation (IMD) was generated for each patient. Univariate and logistic regression analyses examined associations between age, gender, 25-OHD, IMD score and SARS-CoV-2 result in the total cohort and subgroups. RESULTS: In the total cohort, a positive SARS-CoV-2 test was significantly associated with lower 25-OHD levels and higher IMD. A positive test was associated with higher IMD in the male subgroup and with lower 25-OHD levels in those aged >72 years. Low 25-OHD and IMD quintile 5 were separately associated with positive COVID-19 outcome in the cohort. Patients in IMD quintile 5 with vitamin D levels 72 years (OR: 19.07, 95%CI: 1.71-212.25; P = .016). CONCLUSIONS: In this cohort, combined low vitamin D levels and higher social deprivation were most associated with COVID-19 infection. In older age, this combination was even more significant. Our data support the recommendations for normalising vitamin D levels in those with deficient / insufficient levels and in groups at high risk for deficiency. |*COVID-19[MESH] |*Vitamin D Deficiency/epidemiology[MESH] |Aged[MESH] |Chromatography, Liquid[MESH] |England[MESH] |Humans[MESH] |Male[MESH] |RNA, Viral[MESH] |SARS-CoV-2[MESH] |Tandem Mass Spectrometry[MESH]Detectable respiratory SARS-CoV-2 RNA is associated with low vitamin D(epmc).pdf DeepDyve Pubget Overpricing