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10.1038/s41379-021-00793-y http://scihub22266oqcxt.onion/10.1038/s41379-021-00793-y 33795830!8015313!33795830     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mod+Pathol 2021 ; 34 (8): 1456-1467 Nephropedia Template TP {{tp|p=33795830|t=2021. Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience |pdf=|usr=}}{{33795830}} gab.com Text Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience JO: Mod Pathol http://www.kidney.de/pget.php?&tw=1&pmid=33795830 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe and disproportionately affected New York City between March and May 2020. Here, we report on the first 100 COVID-19-positive autopsies performed at the Mount Sinai Hospital in New York City. Autopsies revealed large pulmonary emboli in six cases. Diffuse alveolar damage was present in over 90% of cases. We also report microthrombi in multiple organ systems including the brain, as well as hemophagocytosis. We additionally provide electron microscopic evidence of the presence of the virus in our samples. Laboratory results of our COVID-19 cohort disclose elevated inflammatory markers, abnormal coagulation values, and elevated cytokines IL-6, IL-8, and TNFalpha. Our autopsy series of COVID-19-positive patients reveals that this disease, often conceptualized as a primarily respiratory viral illness, has widespread effects in the body including hypercoagulability, a hyperinflammatory state, and endothelial dysfunction. Targeting of these multisystemic pathways could lead to new treatment avenues as well as combination therapies against SARS-CoV-2 infection. Twit Text FOAVip Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience ????Mod Pathol http://www.kidney.de/pget.php?&tw=1&pmid=33795830 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33795830 #FOAvip English Wikipedia <ref>{{Cite pmid|33795830}}</ref> Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience #MMPMID33795830 Bryce C; Grimes Z; Pujadas E; Ahuja S; Beasley MB; Albrecht R; Hernandez T; Stock A; Zhao Z; AlRasheed MR; Chen J; Li L; Wang D; Corben A; Haines GK 3rd; Westra WH; Umphlett M; Gordon RE; Reidy J; Petersen B; Salem F; Fiel MI; El Jamal SM; Tsankova NM; Houldsworth J; Mussa Z; Veremis B; Sordillo E; Gitman MR; Nowak M; Brody R; Harpaz N; Merad M; Gnjatic S; Liu WC; Schotsaert M; Miorin L; Aydillo Gomez TA; Ramos-Lopez I; Garcia-Sastre A; Donnelly R; Seigler P; Keys C; Cameron J; Moultrie I; Washington KL; Treatman J; Sebra R; Jhang J; Firpo A; Lednicky J; Paniz-Mondolfi A; Cordon-Cardo C; Fowkes ME Mod Pathol 2021[Aug]; 34 (8): 1456-1467 PMID33795830show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated clinical syndrome COVID-19 are causing overwhelming morbidity and mortality around the globe and disproportionately affected New York City between March and May 2020. Here, we report on the first 100 COVID-19-positive autopsies performed at the Mount Sinai Hospital in New York City. Autopsies revealed large pulmonary emboli in six cases. Diffuse alveolar damage was present in over 90% of cases. We also report microthrombi in multiple organ systems including the brain, as well as hemophagocytosis. We additionally provide electron microscopic evidence of the presence of the virus in our samples. Laboratory results of our COVID-19 cohort disclose elevated inflammatory markers, abnormal coagulation values, and elevated cytokines IL-6, IL-8, and TNFalpha. Our autopsy series of COVID-19-positive patients reveals that this disease, often conceptualized as a primarily respiratory viral illness, has widespread effects in the body including hypercoagulability, a hyperinflammatory state, and endothelial dysfunction. Targeting of these multisystemic pathways could lead to new treatment avenues as well as combination therapies against SARS-CoV-2 infection. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Autopsy[MESH] |Blood Coagulation[MESH] |COVID-19/blood/pathology/*physiopathology/virology[MESH] |Cause of Death[MESH] |Cytokines/blood[MESH] |Female[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Inflammation Mediators/blood[MESH] |Lung/pathology/*physiopathology/virology[MESH] |Male[MESH] |Middle Aged[MESH] |New York City[MESH] |Pulmonary Embolism/blood/pathology/*physiopathology/virology[MESH]Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experi(epmc).pdf DeepDyve Pubget Overpricing