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10.1038/s41467-021-22236-7 http://scihub22266oqcxt.onion/10.1038/s41467-021-22236-7 33795692!8016934!33795692     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 2037 Nephropedia Template TP {{tp|p=33795692|t=2021. Systems serology detects functionally distinct coronavirus antibody features in children and elderly |pdf=|usr=}}{{33795692}} gab.com Text Systems serology detects functionally distinct coronavirus antibody features in children and elderly JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33795692 #FOAvip The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses, induced by circulating human coronaviruses (hCoVs), is needed to understand such divergent clinical outcomes. Here we show analysis of coronavirus antibody responses of pre-pandemic healthy children (n = 89), adults (n = 98), elderly (n = 57), and COVID-19 patients (n = 50) by systems serology. Moderate levels of cross-reactive, but non-neutralizing, SARS-CoV-2 antibodies are detected in pre-pandemic healthy individuals. SARS-CoV-2 antigen-specific Fcgamma receptor binding accurately distinguishes COVID-19 patients from healthy individuals, suggesting that SARS-CoV-2 infection induces qualitative changes to antibody Fc, enhancing Fcgamma receptor engagement. Higher cross-reactive SARS-CoV-2 IgA and IgG are observed in healthy elderly, while healthy children display elevated SARS-CoV-2 IgM, suggesting that children have fewer hCoV exposures, resulting in less-experienced but more polyreactive humoral immunity. Age-dependent analysis of COVID-19 patients, confirms elevated class-switched antibodies in elderly, while children have stronger Fc responses which we demonstrate are functionally different. These insights will inform COVID-19 vaccination strategies, improved serological diagnostics and therapeutics. Twit Text FOAVip Systems serology detects functionally distinct coronavirus antibody features in children and elderly ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33795692 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33795692 #FOAvip English Wikipedia <ref>{{Cite pmid|33795692}}</ref> Systems serology detects functionally distinct coronavirus antibody features in children and elderly #MMPMID33795692 Selva KJ; van de Sandt CE; Lemke MM; Lee CY; Shoffner SK; Chua BY; Davis SK; Nguyen THO; Rowntree LC; Hensen L; Koutsakos M; Wong CY; Mordant F; Jackson DC; Flanagan KL; Crowe J; Tosif S; Neeland MR; Sutton P; Licciardi PV; Crawford NW; Cheng AC; Doolan DL; Amanat F; Krammer F; Chappell K; Modhiran N; Watterson D; Young P; Lee WS; Wines BD; Mark Hogarth P; Esterbauer R; Kelly HG; Tan HX; Juno JA; Wheatley AK; Kent SJ; Arnold KB; Kedzierska K; Chung AW Nat Commun 2021[Apr]; 12 (1): 2037 PMID33795692show ga The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses, induced by circulating human coronaviruses (hCoVs), is needed to understand such divergent clinical outcomes. Here we show analysis of coronavirus antibody responses of pre-pandemic healthy children (n = 89), adults (n = 98), elderly (n = 57), and COVID-19 patients (n = 50) by systems serology. Moderate levels of cross-reactive, but non-neutralizing, SARS-CoV-2 antibodies are detected in pre-pandemic healthy individuals. SARS-CoV-2 antigen-specific Fcgamma receptor binding accurately distinguishes COVID-19 patients from healthy individuals, suggesting that SARS-CoV-2 infection induces qualitative changes to antibody Fc, enhancing Fcgamma receptor engagement. Higher cross-reactive SARS-CoV-2 IgA and IgG are observed in healthy elderly, while healthy children display elevated SARS-CoV-2 IgM, suggesting that children have fewer hCoV exposures, resulting in less-experienced but more polyreactive humoral immunity. Age-dependent analysis of COVID-19 patients, confirms elevated class-switched antibodies in elderly, while children have stronger Fc responses which we demonstrate are functionally different. These insights will inform COVID-19 vaccination strategies, improved serological diagnostics and therapeutics. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral/*blood/*immunology[MESH] |Antibody Formation/*immunology[MESH] |COVID-19 Vaccines/immunology[MESH] |COVID-19/immunology[MESH] |Child[MESH] |Child, Preschool[MESH] |Cross Reactions/immunology[MESH] |Humans[MESH] |Immunoglobulin A/blood/immunology[MESH] |Immunoglobulin G/blood/immunology[MESH] |Immunoglobulin M/blood/immunology[MESH] |Middle Aged[MESH] |Receptors, IgG/immunology[MESH] |SARS-CoV-2/*immunology[MESH] |Spike Glycoprotein, Coronavirus/immunology[MESH]Systems serology detects functionally distinct coronavirus antibody fe(epmc).pdf DeepDyve Pubget Overpricing