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10.1016/j.ijid.2021.03.060

http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.03.060
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suck abstract from ncbi


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pmid33794380      Int+J+Infect+Dis 2021 ; 113 Suppl 1 (ä): S78-S81
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  • Bacille Calmette-Guerin (BCG) vaccine and potential cross-protection against SARS-CoV-2 infection - Assumptions, knowns, unknowns and need for developing an accurate scientific evidence base #MMPMID33794380
  • Nachega JB; Maeurer M; Sam-Agudu NA; Chakaya J; Katoto PDM; Zumla A
  • Int J Infect Dis 2021[Dec]; 113 Suppl 1 (ä): S78-S81 PMID33794380show ga
  • After a century of controversies on its usefulness in protection against TB, underlying mechanisms of action, and benefits in various groups and geographical areas, the BCG vaccine is yet again a focus of global attention- this time due to the global COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Recent studies have shown that human CD4+ and CD8+ T-cells primed with a BCG-derived peptide developed high reactivity to its corresponding SARS-CoV-2-derived peptide. Furthermore, BCG vaccine has been shown to substantially increase interferon-gamma (IFN-g) production and its effects on CD4+ T-cells and these non-specific immune responses through adjuvant effect could be harnessed as cross protection against severe forms of COVID-19.The completion of ongoing BGG trials is important as they may shed light on the mechanisms underlying BCG-mediated immunity and could lead to improved efficacy, increased tolerance of treatment, and identification of other ways of combining BCG with other immunotherapies.
  • |*BCG Vaccine[MESH]
  • |*COVID-19[MESH]
  • |Cross Protection[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]


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