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10.1016/j.celrep.2021.108950 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.108950 33794145!7972811!33794145     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2021 ; 35 (1): 108950 Nephropedia Template TP {{tp|p=33794145|t=2021. Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class |pdf=|usr=}}{{33794145}} gab.com Text Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33794145 #FOAvip Antibodies with heavy chains that derive from the VH1-2 gene constitute some of the most potent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing antibodies yet identified. To provide insight into whether these genetic similarities inform common modes of recognition, we determine the structures of the SARS-CoV-2 spike in complex with three VH1-2-derived antibodies: 2-15, 2-43, and H4. All three use VH1-2-encoded motifs to recognize the receptor-binding domain (RBD), with heavy-chain N53I-enhancing binding and light-chain tyrosines recognizing F486(RBD). Despite these similarities, class members bind both RBD-up and -down conformations of the spike, with a subset of antibodies using elongated CDRH3s to recognize glycan N343 on a neighboring RBD-a quaternary interaction accommodated by an increase in RBD separation of up to 12 A. The VH1-2 antibody class, thus, uses modular recognition encoded by modular genetic elements to effect potent neutralization, with the VH-gene component specifying recognition of RBD and the CDRH3 component specifying quaternary interactions. Twit Text FOAVip Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33794145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33794145 #FOAvip English Wikipedia <ref>{{Cite pmid|33794145}}</ref> Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class #MMPMID33794145 Rapp M; Guo Y; Reddem ER; Yu J; Liu L; Wang P; Cerutti G; Katsamba P; Bimela JS; Bahna FA; Mannepalli SM; Zhang B; Kwong PD; Huang Y; Ho DD; Shapiro L; Sheng Z Cell Rep 2021[Apr]; 35 (1): 108950 PMID33794145show ga Antibodies with heavy chains that derive from the VH1-2 gene constitute some of the most potent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing antibodies yet identified. To provide insight into whether these genetic similarities inform common modes of recognition, we determine the structures of the SARS-CoV-2 spike in complex with three VH1-2-derived antibodies: 2-15, 2-43, and H4. All three use VH1-2-encoded motifs to recognize the receptor-binding domain (RBD), with heavy-chain N53I-enhancing binding and light-chain tyrosines recognizing F486(RBD). Despite these similarities, class members bind both RBD-up and -down conformations of the spike, with a subset of antibodies using elongated CDRH3s to recognize glycan N343 on a neighboring RBD-a quaternary interaction accommodated by an increase in RBD separation of up to 12 A. The VH1-2 antibody class, thus, uses modular recognition encoded by modular genetic elements to effect potent neutralization, with the VH-gene component specifying recognition of RBD and the CDRH3 component specifying quaternary interactions. |*Antibodies, Neutralizing/genetics/immunology[MESH] |*Antibodies, Viral/genetics/immunology[MESH] |*COVID-19/genetics/immunology[MESH] |*Immunoglobulin Variable Region/genetics/immunology[MESH] |HEK293 Cells[MESH] |Humans[MESH]Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-(epmc).pdf DeepDyve Pubget Overpricing