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10.15585/mmwr.mm7013e3

http://scihub22266oqcxt.onion/10.15585/mmwr.mm7013e3
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33793460!8022879!33793460
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suck abstract from ncbi


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pmid33793460      MMWR+Morb+Mortal+Wkly+Rep 2021 ; 70 (13): 495-500
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  • Interim Estimates of Vaccine Effectiveness of BNT162b2 and mRNA-1273 COVID-19 Vaccines in Preventing SARS-CoV-2 Infection Among Health Care Personnel, First Responders, and Other Essential and Frontline Workers - Eight U S Locations, December 2020-March 2021 #MMPMID33793460
  • Thompson MG; Burgess JL; Naleway AL; Tyner HL; Yoon SK; Meece J; Olsho LEW; Caban-Martinez AJ; Fowlkes A; Lutrick K; Kuntz JL; Dunnigan K; Odean MJ; Hegmann KT; Stefanski E; Edwards LJ; Schaefer-Solle N; Grant L; Ellingson K; Groom HC; Zunie T; Thiese MS; Ivacic L; Wesley MG; Lamberte JM; Sun X; Smith ME; Phillips AL; Groover KD; Yoo YM; Gerald J; Brown RT; Herring MK; Joseph G; Beitel S; Morrill TC; Mak J; Rivers P; Harris KM; Hunt DR; Arvay ML; Kutty P; Fry AM; Gaglani M
  • MMWR Morb Mortal Wkly Rep 2021[Apr]; 70 (13): 495-500 PMID33793460show ga
  • Messenger RNA (mRNA) BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) COVID-19 vaccines have been shown to be effective in preventing symptomatic COVID-19 in randomized placebo-controlled Phase III trials (1,2); however, the benefits of these vaccines for preventing asymptomatic and symptomatic SARS-CoV-2 (the virus that causes COVID-19) infection, particularly when administered in real-world conditions, is less well understood. Using prospective cohorts of health care personnel, first responders, and other essential and frontline workers* in eight U.S. locations during December 14, 2020-March 13, 2021, CDC routinely tested for SARS-CoV-2 infections every week regardless of symptom status and at the onset of symptoms consistent with COVID-19-associated illness. Among 3,950 participants with no previous laboratory documentation of SARS-CoV-2 infection, 2,479 (62.8%) received both recommended mRNA doses and 477 (12.1%) received only one dose of mRNA vaccine.(dagger) Among unvaccinated participants, 1.38 SARS-CoV-2 infections were confirmed by reverse transcription-polymerase chain reaction (RT-PCR) per 1,000 person-days.( section sign) In contrast, among fully immunized (>/=14 days after second dose) persons, 0.04 infections per 1,000 person-days were reported, and among partially immunized (>/=14 days after first dose and before second dose) persons, 0.19 infections per 1,000 person-days were reported. Estimated mRNA vaccine effectiveness for prevention of infection, adjusted for study site, was 90% for full immunization and 80% for partial immunization. These findings indicate that authorized mRNA COVID-19 vaccines are effective for preventing SARS-CoV-2 infection, regardless of symptom status, among working-age adults in real-world conditions. COVID-19 vaccination is recommended for all eligible persons.
  • |*Emergency Responders/statistics & numerical data[MESH]
  • |*Health Personnel/statistics & numerical data[MESH]
  • |Adolescent[MESH]
  • |Adult[MESH]
  • |BNT162 Vaccine[MESH]
  • |COVID-19 Nucleic Acid Testing[MESH]
  • |COVID-19 Vaccines/administration & dosage/*immunology[MESH]
  • |COVID-19/epidemiology/*prevention & control[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Occupational Diseases/*prevention & control[MESH]
  • |Occupations/*classification[MESH]
  • |Prospective Studies[MESH]
  • |United States/epidemiology[MESH]
  • |Vaccines, Synthetic/immunology[MESH]
  • |Young Adult[MESH]


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