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10.1111/apm.13129 http://scihub22266oqcxt.onion/10.1111/apm.13129 33792109!8250891!33792109     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       APMIS 2021 ; 129 (5): 271-279 Nephropedia Template TP {{tp|p=33792109|t=2021. Reduced frequency of T helper 17 and T helper 1 cells and their association with critical coronavirus disease 2019 |pdf=|usr=}}{{33792109}} gab.com Text Reduced frequency of T helper 17 and T helper 1 cells and their association with critical coronavirus disease 2019 JO: APMIS http://www.kidney.de/pget.php?&tw=1&pmid=33792109 #FOAvip There is very little knowledge about the immune responses, particularly cellular immunity to coronavirus disease 2019 (COVID-19). The main objective of this study was to evaluate the frequency of T helper (Th) cell subtypes, including Th1, Th17, and Treg cells, in moderate-to-severe and critical COVID-19 patients compared to healthy controls. Twenty-nine moderate-to-severe and 13 critical patients confirmed for COVID-19, and 15 healthy subjects were included in this study. Interferon-gamma (IFN-gamma)-producing Th1 and interleukin-17A-producing Th17 and Treg cells in peripheral blood were measured with flow cytometry. The frequency of Th1 and Th17 was significantly decreased in critical patients compared to healthy subjects (aMD: -2.76 and - 2.34) and moderate-to-severe patients (aMD: -1.89 and - 1.89), respectively (p < 0.05). Differences were not significant between moderate-to-severe patients and healthy subjects for both Th1 (p = 0.358) and Th17 (p = 0.535), respectively. In contrast, significant difference was not observed between study subjects regarding the frequency of Treg cells. Patients with critical COVID-19 had a markedly lower Th1/Treg and Th17/Treg ratios compared with the controls and moderate-to-severe cases. Our study showed a dysregulated balance of Th1 and Th17 cells and its relation to the severity of COVID-19. Twit Text FOAVip Reduced frequency of T helper 17 and T helper 1 cells and their association with critical coronavirus disease 2019 ????APMIS http://www.kidney.de/pget.php?&tw=1&pmid=33792109 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33792109 #FOAvip English Wikipedia <ref>{{Cite pmid|33792109}}</ref> Reduced frequency of T helper 17 and T helper 1 cells and their association with critical coronavirus disease 2019 #MMPMID33792109 Shahbazi M; Jafari M; Moulana Z; Sepidarkish M; Bagherzadeh M; Rezanejad M; Mirzakhani M; Javanian M; Bayani M; Sadeghi-Haddad-Zavareh M; Mehdinezhad H; Ghadimi R; Ghasemzadeh M; Shokuhi Rad A; Mohammadnia-Afrouzi M APMIS 2021[May]; 129 (5): 271-279 PMID33792109show ga There is very little knowledge about the immune responses, particularly cellular immunity to coronavirus disease 2019 (COVID-19). The main objective of this study was to evaluate the frequency of T helper (Th) cell subtypes, including Th1, Th17, and Treg cells, in moderate-to-severe and critical COVID-19 patients compared to healthy controls. Twenty-nine moderate-to-severe and 13 critical patients confirmed for COVID-19, and 15 healthy subjects were included in this study. Interferon-gamma (IFN-gamma)-producing Th1 and interleukin-17A-producing Th17 and Treg cells in peripheral blood were measured with flow cytometry. The frequency of Th1 and Th17 was significantly decreased in critical patients compared to healthy subjects (aMD: -2.76 and - 2.34) and moderate-to-severe patients (aMD: -1.89 and - 1.89), respectively (p < 0.05). Differences were not significant between moderate-to-severe patients and healthy subjects for both Th1 (p = 0.358) and Th17 (p = 0.535), respectively. In contrast, significant difference was not observed between study subjects regarding the frequency of Treg cells. Patients with critical COVID-19 had a markedly lower Th1/Treg and Th17/Treg ratios compared with the controls and moderate-to-severe cases. Our study showed a dysregulated balance of Th1 and Th17 cells and its relation to the severity of COVID-19. |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |CD4 Lymphocyte Count[MESH] |COVID-19/*immunology/pathology[MESH] |Critical Illness[MESH] |Female[MESH] |Flow Cytometry[MESH] |Humans[MESH] |Interferon-gamma/biosynthesis[MESH] |Interleukin-17/biosynthesis[MESH] |Male[MESH] |Middle Aged[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH] |T-Lymphocytes, Regulatory/*immunology[MESH] |Th1 Cells/*immunology[MESH] |Th17 Cells/*immunology[MESH]Reduced frequency of T helper 17 and T helper 1 cells and their associ(epmc).pdf DeepDyve Pubget Overpricing