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10.1101/2021.03.23.21253487

http://scihub22266oqcxt.onion/10.1101/2021.03.23.21253487
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33791731!8010763!33791731
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suck abstract from ncbi


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pmid33791731      medRxiv 2021 ; ä (ä): ä
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  • Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19 #MMPMID33791731
  • Tsitsiklis A; Zha BS; Byrne A; DeVoe C; Rackaityte E; Levan S; Sunshine S; Mick E; Ghale R; Love C; Tarashansky AJ; Pisco A; Albright J; Jauregui A; Sarma A; Neff N; Serpa PH; Deiss TJ; Kistler A; Carrillo S; Ansel KM; Leligdowicz A; Christenson S; Detweiler A; Jones NG; Wu B; Darmanis S; Lynch SV; DeRisi JL; Matthay MA; Hendrickson CM; Kangelaris KN; Krummel MF; Woodruff PG; Erle DJ; Rosenberg O; Calfee CS; Langelier CR
  • medRxiv 2021[Nov]; ä (ä): ä PMID33791731show ga
  • Secondary bacterial infections, including ventilator-associated pneumonia (VAP), lead to worse clinical outcomes and increased mortality following viral respiratory infections including in patients with coronavirus disease 2019 (COVID-19). Using a combination of tracheal aspirate bulk and single-cell RNA sequencing we assessed lower respiratory tract immune responses and microbiome dynamics in 23 COVID-19 patients, 10 of whom developed VAP, and eight critically ill uninfected controls. At a median of three days (range: 2-4 days) before VAP onset we observed a transcriptional signature of bacterial infection. At a median of 15 days prior to VAP onset (range: 8-38 days), we observed a striking impairment in immune signaling in COVID-19 patients who developed VAP. Longitudinal metatranscriptomic analysis revealed disruption of lung microbiome community composition in patients with VAP, providing a connection between dysregulated immune signaling and outgrowth of opportunistic pathogens. These findings suggest that COVID-19 patients who develop VAP have impaired antibacterial immune defense detectable weeks before secondary infection onset.
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