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10.3389/fcimb.2021.598875 http://scihub22266oqcxt.onion/10.3389/fcimb.2021.598875 33791232!8005637!33791232     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Infect+Microbiol 2021 ; 11 (ä): 598875 Nephropedia Template TP {{tp|p=33791232|t=2021. Perspectives and Challenges in the Fight Against COVID-19: The Role of Genetic Variability |pdf=|usr=}}{{33791232}} gab.com Text Perspectives and Challenges in the Fight Against COVID-19: The Role of Genetic Variability JO: Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33791232 #FOAvip In the last year, the advent of the COVID-19 pandemic brought a new consideration for the multidisciplinary sciences. The unknown mechanisms of infection used by SARS-CoV-2 and the absence of effective antiviral pharmacological therapy, diagnosis methods, and vaccines evoked scientific efforts on the COVID-19 outcome. In general, COVID-19 clinical features are a result of local and systemic inflammatory processes that are enhanced by some preexistent comorbidities, such as diabetes, obesity, cardiovascular, and pulmonary diseases, and biological factors, like gender and age. However, the discrepancies in COVID-19 clinical signs observed among those patients lead to investigations about the critical factors that deeply influence disease severity and death. Herein, we present the viral infection mechanisms and its consequences after blocking the angiotensin-converting enzyme 2 (ACE2) axis in different tissues and the progression of inflammatory and immunological reactions, especially the influence of genetic features on those differential clinical responses. Furthermore, we discuss the role of genotype as an essential indicator of COVID-19 susceptibility, considering the expression profiles, polymorphisms, gene identification, and epigenetic modifications of viral entry factors and their recognition, as well as the infection effects on cell signaling molecule expression, which amplifies disease severity. Twit Text FOAVip Perspectives and Challenges in the Fight Against COVID-19: The Role of Genetic Variability ????Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33791232 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33791232 #FOAvip English Wikipedia <ref>{{Cite pmid|33791232}}</ref> Perspectives and Challenges in the Fight Against COVID-19: The Role of Genetic Variability #MMPMID33791232 Guilger-Casagrande M; de Barros CT; Antunes VAN; de Araujo DR; Lima R Front Cell Infect Microbiol 2021[]; 11 (ä): 598875 PMID33791232show ga In the last year, the advent of the COVID-19 pandemic brought a new consideration for the multidisciplinary sciences. The unknown mechanisms of infection used by SARS-CoV-2 and the absence of effective antiviral pharmacological therapy, diagnosis methods, and vaccines evoked scientific efforts on the COVID-19 outcome. In general, COVID-19 clinical features are a result of local and systemic inflammatory processes that are enhanced by some preexistent comorbidities, such as diabetes, obesity, cardiovascular, and pulmonary diseases, and biological factors, like gender and age. However, the discrepancies in COVID-19 clinical signs observed among those patients lead to investigations about the critical factors that deeply influence disease severity and death. Herein, we present the viral infection mechanisms and its consequences after blocking the angiotensin-converting enzyme 2 (ACE2) axis in different tissues and the progression of inflammatory and immunological reactions, especially the influence of genetic features on those differential clinical responses. Furthermore, we discuss the role of genotype as an essential indicator of COVID-19 susceptibility, considering the expression profiles, polymorphisms, gene identification, and epigenetic modifications of viral entry factors and their recognition, as well as the infection effects on cell signaling molecule expression, which amplifies disease severity. |Angiotensin-Converting Enzyme 2/genetics/*metabolism[MESH] |Antiviral Agents/pharmacology[MESH] |COVID-19/*pathology[MESH] |Cytokines/blood/immunology[MESH] |Humans[MESH] |Renin-Angiotensin System/*physiology[MESH] |Risk Factors[MESH] |SARS-CoV-2/genetics/*immunology[MESH]Perspectives and Challenges in the Fight Against COVID-19: The Role of(epmc).pdf DeepDyve Pubget Overpricing