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10.1136/gutjnl-2020-323826 http://scihub22266oqcxt.onion/10.1136/gutjnl-2020-323826 33789966!8042598!33789966     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Gut 2021 ; 70 (7): 1253-1265 Nephropedia Template TP {{tp|p=33789966|t=2021. Alterations in the human oral and gut microbiomes and lipidomics in COVID-19 |pdf=|usr=}}{{33789966}} gab.com Text Alterations in the human oral and gut microbiomes and lipidomics in COVID-19 JO: Gut http://www.kidney.de/pget.php?&tw=1&pmid=33789966 #FOAvip OBJECTIVE: To characterise the oral microbiome, gut microbiome and serum lipid profiles in patients with active COVID-19 and recovered patients; evaluate the potential of the microbiome as a non-invasive biomarker for COVID-19; and explore correlations between the microbiome and lipid profile. DESIGN: We collected and sequenced 392 tongue-coating samples, 172 faecal samples and 155 serum samples from Central China and East China. We characterised microbiome and lipid molecules, constructed microbial classifiers in discovery cohort and verified their diagnostic potential in 74 confirmed patients (CPs) from East China and 37 suspected patients (SPs) with IgG positivity. RESULTS: Oral and faecal microbial diversity was significantly decreased in CPs versus healthy controls (HCs). Compared with HCs, butyric acid-producing bacteria were decreased and lipopolysaccharide-producing bacteria were increased in CPs in oral cavity. The classifiers based on 8 optimal oral microbial markers (7 faecal microbial markers) achieved good diagnostic efficiency in different cohorts. Importantly, diagnostic efficacy reached 87.24% in the cross-regional cohort. Moreover, the classifiers successfully diagnosed SPs with IgG antibody positivity as CPs, and diagnostic efficacy reached 92.11% (98.01% of faecal microbiome). Compared with CPs, 47 lipid molecules, including sphingomyelin (SM)(d40:4), SM(d38:5) and monoglyceride(33:5), were depleted, and 122 lipid molecules, including phosphatidylcholine(36:4p), phosphatidylethanolamine (PE)(16:0p/20:5) and diglyceride(20:1/18:2), were enriched in confirmed patients recovery. CONCLUSION: This study is the first to characterise the oral microbiome in COVID-19, and oral microbiomes and lipid alterations in recovered patients, to explore their correlations and to report the successful establishment and validation of a diagnostic model for COVID-19. Twit Text FOAVip Alterations in the human oral and gut microbiomes and lipidomics in COVID-19 ????Gut http://www.kidney.de/pget.php?&tw=1&pmid=33789966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33789966 #FOAvip English Wikipedia <ref>{{Cite pmid|33789966}}</ref> Alterations in the human oral and gut microbiomes and lipidomics in COVID-19 #MMPMID33789966 Ren Z; Wang H; Cui G; Lu H; Wang L; Luo H; Chen X; Ren H; Sun R; Liu W; Liu X; Liu C; Li A; Wang X; Rao B; Yuan C; Zhang H; Sun J; Chen X; Li B; Hu C; Wu Z; Yu Z; Kan Q; Li L Gut 2021[Jul]; 70 (7): 1253-1265 PMID33789966show ga OBJECTIVE: To characterise the oral microbiome, gut microbiome and serum lipid profiles in patients with active COVID-19 and recovered patients; evaluate the potential of the microbiome as a non-invasive biomarker for COVID-19; and explore correlations between the microbiome and lipid profile. DESIGN: We collected and sequenced 392 tongue-coating samples, 172 faecal samples and 155 serum samples from Central China and East China. We characterised microbiome and lipid molecules, constructed microbial classifiers in discovery cohort and verified their diagnostic potential in 74 confirmed patients (CPs) from East China and 37 suspected patients (SPs) with IgG positivity. RESULTS: Oral and faecal microbial diversity was significantly decreased in CPs versus healthy controls (HCs). Compared with HCs, butyric acid-producing bacteria were decreased and lipopolysaccharide-producing bacteria were increased in CPs in oral cavity. The classifiers based on 8 optimal oral microbial markers (7 faecal microbial markers) achieved good diagnostic efficiency in different cohorts. Importantly, diagnostic efficacy reached 87.24% in the cross-regional cohort. Moreover, the classifiers successfully diagnosed SPs with IgG antibody positivity as CPs, and diagnostic efficacy reached 92.11% (98.01% of faecal microbiome). Compared with CPs, 47 lipid molecules, including sphingomyelin (SM)(d40:4), SM(d38:5) and monoglyceride(33:5), were depleted, and 122 lipid molecules, including phosphatidylcholine(36:4p), phosphatidylethanolamine (PE)(16:0p/20:5) and diglyceride(20:1/18:2), were enriched in confirmed patients recovery. CONCLUSION: This study is the first to characterise the oral microbiome in COVID-19, and oral microbiomes and lipid alterations in recovered patients, to explore their correlations and to report the successful establishment and validation of a diagnostic model for COVID-19. |Adult[MESH] |COVID-19/*blood/diagnosis/*microbiology[MESH] |Case-Control Studies[MESH] |China[MESH] |Cohort Studies[MESH] |Feces/*microbiology[MESH] |Female[MESH] |Gastrointestinal Microbiome[MESH] |Humans[MESH] |Lipidomics[MESH] |Lipids/*blood[MESH] |Male[MESH] |Middle Aged[MESH]Alterations in the human oral and gut microbiomes and lipidomics in CO(epmc).pdf DeepDyve Pubget Overpricing