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10.1016/j.lfs.2021.119437 http://scihub22266oqcxt.onion/10.1016/j.lfs.2021.119437 33789145!8005319!33789145     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2021 ; 276 (ä): 119437 Nephropedia Template TP {{tp|p=33789145|t=2021. Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2 |pdf=|usr=}}{{33789145}} gab.com Text Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2 JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33789145 #FOAvip In Coronavirus disease 2019 (COVID-19), a decreased number of regulatory T (Treg) cells and their mediated factors lead to a hyperinflammatory state due to overactivation of the inflammatory cells and factors during the infection. In the current study, we evaluated the Nanocurcumin effects on the Treg cell population and corresponding factors in mild and severe COVID-19 patients. To investigate the Nanocurcumin effects, 80 COVID-19 patients (40 at the severe stage and 40 at the mild stage) were selected and classified into Nanocurcumin and placebo arms. In both the Nanocurcumin and placebo groups, the Treg cell frequency, the gene expression of Treg transcription factor forkhead box P3 (FoxP3), and cytokines (IL-10, IL-35, and TGF-beta), as well as the serum levels of cytokines were measured before and after treatment. In both mild and severe COVID-19 patients, Nanocurcumin could considerably upregulate the frequency of Treg cells, the expression levels of FoxP3, IL-10, IL-35, and TGF-beta, as well as the serum secretion levels of cytokines in the Nanocurcumin-treated group compared to the placebo group. The abovementioned factors were remarkably increased in the post-treatment with Nanocurcumin before pre-treatment conditions. By contrast, it has been observed no notable alteration in the placebo group. Our findings revealed the SinaCurcumin(R) effective function in a significant increase in the number of Treg cells and their mediated factors in the Nanocurcumin group than in the placebo group in both mild and severe patients. Hence, it would be an efficient therapeutic agent in rehabilitating COVID-19 infected patients. Twit Text FOAVip Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2 ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33789145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33789145 #FOAvip English Wikipedia <ref>{{Cite pmid|33789145}}</ref> Nanocurcumin improves Treg cell responses in patients with mild and severe SARS-CoV2 #MMPMID33789145 Tahmasebi S; Saeed BQ; Temirgalieva E; Yumashev AV; El-Esawi MA; Navashenaq JG; Valizadeh H; Sadeghi A; Aslani S; Yousefi M; Jadidi-Niaragh F; Adigozalou J; Ahmadi M; Roshangar L Life Sci 2021[Jul]; 276 (ä): 119437 PMID33789145show ga In Coronavirus disease 2019 (COVID-19), a decreased number of regulatory T (Treg) cells and their mediated factors lead to a hyperinflammatory state due to overactivation of the inflammatory cells and factors during the infection. In the current study, we evaluated the Nanocurcumin effects on the Treg cell population and corresponding factors in mild and severe COVID-19 patients. To investigate the Nanocurcumin effects, 80 COVID-19 patients (40 at the severe stage and 40 at the mild stage) were selected and classified into Nanocurcumin and placebo arms. In both the Nanocurcumin and placebo groups, the Treg cell frequency, the gene expression of Treg transcription factor forkhead box P3 (FoxP3), and cytokines (IL-10, IL-35, and TGF-beta), as well as the serum levels of cytokines were measured before and after treatment. In both mild and severe COVID-19 patients, Nanocurcumin could considerably upregulate the frequency of Treg cells, the expression levels of FoxP3, IL-10, IL-35, and TGF-beta, as well as the serum secretion levels of cytokines in the Nanocurcumin-treated group compared to the placebo group. The abovementioned factors were remarkably increased in the post-treatment with Nanocurcumin before pre-treatment conditions. By contrast, it has been observed no notable alteration in the placebo group. Our findings revealed the SinaCurcumin(R) effective function in a significant increase in the number of Treg cells and their mediated factors in the Nanocurcumin group than in the placebo group in both mild and severe patients. Hence, it would be an efficient therapeutic agent in rehabilitating COVID-19 infected patients. |*COVID-19 Drug Treatment[MESH] |Adult[MESH] |Aged[MESH] |COVID-19/immunology/virology[MESH] |Curcumin/*pharmacology[MESH] |Cytokines/drug effects/immunology[MESH] |Female[MESH] |Forkhead Transcription Factors/genetics/metabolism[MESH] |Gene Expression/drug effects[MESH] |Humans[MESH] |Interleukin-10/immunology[MESH] |Interleukins/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Nanomedicine/methods[MESH] |RNA, Viral/metabolism[MESH] |SARS-CoV-2/drug effects/isolation & purification[MESH] |T-Lymphocytes, Regulatory/*drug effects/immunology[MESH] |Th17 Cells/immunology[MESH]Nanocurcumin improves Treg cell responses in patients with mild and se(epmc).pdf DeepDyve Pubget Overpricing