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suck abstract from ncbi


10.1016/j.chom.2021.02.020

http://scihub22266oqcxt.onion/10.1016/j.chom.2021.02.020
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33789086!7919536!33789086
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suck abstract from ncbi

pmid33789086      Cell+Host+Microbe 2021 ; 29 (4): 508-515
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  • The variant gambit: COVID-19 s next move #MMPMID33789086
  • Plante JA; Mitchell BM; Plante KS; Debbink K; Weaver SC; Menachery VD
  • Cell Host Microbe 2021[Apr]; 29 (4): 508-515 PMID33789086show ga
  • More than a year after its emergence, COVID-19, the disease caused by SARS-CoV-2, continues to plague the world and dominate our daily lives. Even with the development of effective vaccines, this coronavirus pandemic continues to cause a fervor with the identification of major new variants hailing from the United Kingdom, South Africa, Brazil, and California. Coupled with worries over a distinct mink strain that has caused human infections and potential for further mutations, SARS-CoV-2 variants bring concerns for increased spread and escape from both vaccine and natural infection immunity. Here, we outline factors driving SARS-CoV-2 variant evolution, explore the potential impact of specific mutations, examine the risk of further mutations, and consider the experimental studies needed to understand the threat these variants pose. In this review, Plante et al. examine SARS-CoV-2 variants including B.1.1.7 (UK), B.1.351 (RSA), P.1 (Brazil), and B.1.429 (California). They focus on what factors contribute to variant emergence, mutations in and outside the spike protein, and studies needed to understand the impact of variants on infection, transmission, and vaccine efficacy.
  • |*Mutation[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2/*genetics/immunology[MESH]


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