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10.1016/j.chom.2021.03.005 http://scihub22266oqcxt.onion/10.1016/j.chom.2021.03.005 33789084!7953435!33789084     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Host+Microbe 2021 ; 29 (5): 819-833.e7 Nephropedia Template TP {{tp|p=33789084|t=2021. Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite |pdf=|usr=}}{{33789084}} gab.com Text Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33789084 #FOAvip Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral spike. While RBD-directed antibodies have been extensively studied, far less is known about NTD-directed antibodies. Here, we report cryo-EM and crystal structures for seven potent NTD-directed neutralizing antibodies in complex with spike or isolated NTD. These structures defined several antibody classes, with at least one observed in multiple convalescent donors. The structures revealed that all seven antibodies target a common surface, bordered by glycans N17, N74, N122, and N149. This site-formed primarily by a mobile beta-hairpin and several flexible loops-was highly electropositive, located at the periphery of the spike, and the largest glycan-free surface of NTD facing away from the viral membrane. Thus, in contrast to neutralizing RBD-directed antibodies that recognize multiple non-overlapping epitopes, potent NTD-directed neutralizing antibodies appear to target a single supersite. Twit Text FOAVip Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=33789084 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33789084 #FOAvip English Wikipedia <ref>{{Cite pmid|33789084}}</ref> Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite #MMPMID33789084 Cerutti G; Guo Y; Zhou T; Gorman J; Lee M; Rapp M; Reddem ER; Yu J; Bahna F; Bimela J; Huang Y; Katsamba PS; Liu L; Nair MS; Rawi R; Olia AS; Wang P; Zhang B; Chuang GY; Ho DD; Sheng Z; Kwong PD; Shapiro L Cell Host Microbe 2021[May]; 29 (5): 819-833.e7 PMID33789084show ga Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral spike. While RBD-directed antibodies have been extensively studied, far less is known about NTD-directed antibodies. Here, we report cryo-EM and crystal structures for seven potent NTD-directed neutralizing antibodies in complex with spike or isolated NTD. These structures defined several antibody classes, with at least one observed in multiple convalescent donors. The structures revealed that all seven antibodies target a common surface, bordered by glycans N17, N74, N122, and N149. This site-formed primarily by a mobile beta-hairpin and several flexible loops-was highly electropositive, located at the periphery of the spike, and the largest glycan-free surface of NTD facing away from the viral membrane. Thus, in contrast to neutralizing RBD-directed antibodies that recognize multiple non-overlapping epitopes, potent NTD-directed neutralizing antibodies appear to target a single supersite. |Antibodies, Neutralizing/chemistry/*immunology[MESH] |Antibodies, Viral/chemistry/*immunology[MESH] |Humans[MESH] |Mutation[MESH] |Protein Conformation[MESH] |Protein Domains[MESH] |SARS-CoV-2/*immunology[MESH]Potent SARS-CoV-2 neutralizing antibodies directed against spike N-ter(epmc).pdf DeepDyve Pubget Overpricing