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10.1111/ijcp.14191 http://scihub22266oqcxt.onion/10.1111/ijcp.14191 33788370!8250364!33788370     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33788370&cmd=llinks): Failed to open stream: HTTP request failed! 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How fast should social restrictions be eased in England as COVID-19 vaccinations are rolled out?|pdf=|usr=}}{{33788370}} gab.com Text How fast should social restrictions be eased in England as COVID-19 vaccinations are rolled out JO: Int J Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=33788370 #FOAvip INTRODUCTION: Vaccination against the COVID-19 virus began in December 2020 in the UK and into Spring 2021 has been running at 5% population/week. High levels of social restrictions were implemented for the third time in January 2021 to control the second wave and resulting increases in hospitalisations and deaths. Easing those restrictions must balance multiple challenging priorities, weighing the risk of more deaths and hospitalisations against damage done to mental health, incomes and standards of living, education and provision of non-Covid-19 healthcare. METHODS: Weekly and monthly officially published data for 2020/21 were used to estimate the influence of seasonality and social restrictions on the spread of COVID-19 by age group, on the economy and on healthcare services. These factors were combined with the estimated impact of vaccinations and immunity from past infections into a model that retrospectively reflected the actual numbers of reported deaths closely both in 2020 and early 2021. The model was applied prospectively to the next 6 months to evaluate the impact of different speeds of easing social restrictions. RESULTS: The results show vaccinations as significantly reducing the number of hospitalisations and deaths. The central estimate is that relative to rapid easing, the avoided loss of 57 000 life-years from a strategy of relatively slow easing over the next several months comes at a cost in terms of GDP reduction of around pound0.4 million/life-year loss avoided. This is over 10 times higher than the usual limit the NHS uses for spending against Quality Adjusted Life Years (QALYs) saved. Alternative assumptions for key factors affecting the spread of the virus give significantly different trade-offs between costs and benefits of different speeds of easing. Disruption of non-Covid-19 Healthcare provision also increases in times of higher levels of social restrictions. CONCLUSION: In most cases, the results favour a somewhat faster easing of restrictions in England than current policy implies. Twit Text FOAVip How fast should social restrictions be eased in England as COVID-19 vaccinations are rolled out ????Int J Clin Pract http://www.kidney.de/pget.php?&tw=1&pmid=33788370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33788370 #FOAvip English Wikipedia <ref>{{Cite pmid|33788370}}</ref> How fast should social restrictions be eased in England as COVID-19 vaccinations are rolled out? #MMPMID33788370 Miles DK; Heald AH; Stedman M Int J Clin Pract 2021[Jul]; 75 (7): e14191 PMID33788370show ga INTRODUCTION: Vaccination against the COVID-19 virus began in December 2020 in the UK and into Spring 2021 has been running at 5% population/week. High levels of social restrictions were implemented for the third time in January 2021 to control the second wave and resulting increases in hospitalisations and deaths. Easing those restrictions must balance multiple challenging priorities, weighing the risk of more deaths and hospitalisations against damage done to mental health, incomes and standards of living, education and provision of non-Covid-19 healthcare. METHODS: Weekly and monthly officially published data for 2020/21 were used to estimate the influence of seasonality and social restrictions on the spread of COVID-19 by age group, on the economy and on healthcare services. These factors were combined with the estimated impact of vaccinations and immunity from past infections into a model that retrospectively reflected the actual numbers of reported deaths closely both in 2020 and early 2021. The model was applied prospectively to the next 6 months to evaluate the impact of different speeds of easing social restrictions. RESULTS: The results show vaccinations as significantly reducing the number of hospitalisations and deaths. The central estimate is that relative to rapid easing, the avoided loss of 57 000 life-years from a strategy of relatively slow easing over the next several months comes at a cost in terms of GDP reduction of around pound0.4 million/life-year loss avoided. This is over 10 times higher than the usual limit the NHS uses for spending against Quality Adjusted Life Years (QALYs) saved. Alternative assumptions for key factors affecting the spread of the virus give significantly different trade-offs between costs and benefits of different speeds of easing. Disruption of non-Covid-19 Healthcare provision also increases in times of higher levels of social restrictions. CONCLUSION: In most cases, the results favour a somewhat faster easing of restrictions in England than current policy implies. |*COVID-19[MESH] |*COVID-19 Vaccines[MESH] |England[MESH] |Humans[MESH] |Retrospective Studies[MESH] |SARS-CoV-2[MESH]How fast should social restrictions be eased in England as COVID-19 va(epmc).pdf DeepDyve Pubget Overpricing