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10.1002/jmv.26982

http://scihub22266oqcxt.onion/10.1002/jmv.26982
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33788281!8250392!33788281
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suck abstract from ncbi


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pmid33788281      J+Med+Virol 2021 ; 93 (7): 4612-4615
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  • Antibody response to SARS-CoV-2 vaccination is extremely vivacious in subjects with previous SARS-CoV-2 infection #MMPMID33788281
  • Callegaro A; Borleri D; Farina C; Napolitano G; Valenti D; Rizzi M; Maggiolo F
  • J Med Virol 2021[Jul]; 93 (7): 4612-4615 PMID33788281show ga
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic calls for rapid actions, now principally oriented to a world-wide vaccination campaign. In this study we verified if, in individuals with a previous SARS-CoV-2 infection, a single dose of messenger RNA (mRNA) vaccine would be immunologically equivalent to a full vaccine schedule in naive individuals. Health care workers (184) with a previous SARS-CoV-2 infection were sampled soon before the second dose of vaccine and between 7 and 10 days after the second dose, the last sampling time was applied to SARS-CoV-2 naive individuals, too. Antibodies against SARS-CoV-2 were measured using Elecsys Anti-SARS-CoV-2 S immunoassay. The study was powered for non-inferiority. We used non parametric tests and Pearson correlation test to perform inferential analysis. After a single vaccine injection, the median titer of specific antibodies in individuals with previous coronavirus disease 2019 was 30.527 U/ml (interquartile range [IQR]: 19.992-39.288) and in subjects with previous SARS-CoV-2 asymptomatic infection was 19.367.5 U/ml (IQR: 14.688-31.353) (p = .032). Both results were far above the median titer in naive individuals after a full vaccination schedule: 1974.5 U/ml (IQR: 895-3455) (p < .0001). Adverse events after vaccine injection were more frequent after the second dose of vaccine (mean: 0.95; 95% confidence interval [CI]: 0.75-1.14 vs. mean: 1.91; 95% CI: 1.63-2.19) (p < .0001) and in exposed compared to naive (mean: 1.63; 95% CI: 1.28-1.98 vs. mean: 2.35; 95% CI: 1.87-2.82) (p = .015). In SARS-CoV-2 naturally infected individuals a single mRNA vaccine dose seems sufficient to reach immunity. Modifying current dosing schedules would speed-up vaccination campaigns.
  • |Adult[MESH]
  • |Antibodies, Viral/blood/*immunology[MESH]
  • |Asymptomatic Infections[MESH]
  • |COVID-19 Vaccines/administration & dosage/adverse effects/*immunology[MESH]
  • |COVID-19/diagnosis/*immunology/prevention & control[MESH]
  • |Female[MESH]
  • |Health Personnel[MESH]
  • |Humans[MESH]
  • |Immunization Schedule[MESH]
  • |Immunization, Secondary[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2/*immunology/isolation & purification[MESH]
  • |Spike Glycoprotein, Coronavirus/immunology[MESH]
  • |Vaccination[MESH]
  • |Vaccines, Synthetic/administration & dosage/adverse effects/immunology[MESH]


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