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10.1002/eji.202049163 http://scihub22266oqcxt.onion/10.1002/eji.202049163 33788264!8250224!33788264     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2021 ; 51 (6): 1449-1460 Nephropedia Template TP {{tp|p=33788264|t=2021. Increased B-cell activity with consumption of activated monocytes in severe COVID-19 patients |pdf=|usr=}}{{33788264}} gab.com Text Increased B-cell activity with consumption of activated monocytes in severe COVID-19 patients JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33788264 #FOAvip The pathogenesis of autoimmune complications triggered by SARS-CoV2 has not been completely elucidated. Here, we performed an analysis of the cellular immune status, cell ratios, and monocyte populations of patients with COVID-19 treated in the intensive care unit (ICU) (cohort 1, N = 23) and normal care unit (NCU) (cohort 2, n = 10) compared with control groups: patients treated in ICU for noninfectious reasons (cohort 3, n = 30) and patients treated in NCU for infections other than COVID-19 (cohort 4, n = 21). Patients in cohort 1 presented significant differences in comparison with the other cohorts, including reduced frequencies of lymphocytes, reduced CD8+T-cell count, reduced percentage of activated and intermediate monocytes and an increased B/T8 cell ratio. Over time, patients in cohort 1 who died presented with lower counts of B, T, CD4(+) T, CD8(+) T-lymphocytes, NK cells, and activated monocytes. The B/T8 ratio was significantly lower in the group of survivors. In cohort 1, significantly higher levels of IgG1 and IgG3 were found, whereas cohort 3 presented higher levels of IgG3 compared to controls. Among many immune changes, an elevated B/T8-cell ratio and a reduced rate of activated monocytes were mainly observed in patients with severe COVID-19. Both parameters were associated with death in cohort 1. Twit Text FOAVip Increased B-cell activity with consumption of activated monocytes in severe COVID-19 patients ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33788264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33788264 #FOAvip English Wikipedia <ref>{{Cite pmid|33788264}}</ref> Increased B-cell activity with consumption of activated monocytes in severe COVID-19 patients #MMPMID33788264 Kos I; Balensiefer B; Lesan V; Kaddu-Mulindwa D; Thurner L; Christofyllakis K; Bittenbring JT; Ahlgrimm M; Seiffert M; Wagenpfeil S; Bewarder Y; Neumann F; Rixecker T; Smola S; Link A; Krawczyk M; Lammert F; Lepper PM; Bals R; Stilgenbauer S; Bewarder M Eur J Immunol 2021[Jun]; 51 (6): 1449-1460 PMID33788264show ga The pathogenesis of autoimmune complications triggered by SARS-CoV2 has not been completely elucidated. Here, we performed an analysis of the cellular immune status, cell ratios, and monocyte populations of patients with COVID-19 treated in the intensive care unit (ICU) (cohort 1, N = 23) and normal care unit (NCU) (cohort 2, n = 10) compared with control groups: patients treated in ICU for noninfectious reasons (cohort 3, n = 30) and patients treated in NCU for infections other than COVID-19 (cohort 4, n = 21). Patients in cohort 1 presented significant differences in comparison with the other cohorts, including reduced frequencies of lymphocytes, reduced CD8+T-cell count, reduced percentage of activated and intermediate monocytes and an increased B/T8 cell ratio. Over time, patients in cohort 1 who died presented with lower counts of B, T, CD4(+) T, CD8(+) T-lymphocytes, NK cells, and activated monocytes. The B/T8 ratio was significantly lower in the group of survivors. In cohort 1, significantly higher levels of IgG1 and IgG3 were found, whereas cohort 3 presented higher levels of IgG3 compared to controls. Among many immune changes, an elevated B/T8-cell ratio and a reduced rate of activated monocytes were mainly observed in patients with severe COVID-19. Both parameters were associated with death in cohort 1. |Aged[MESH] |Antibodies, Viral/immunology[MESH] |B-Lymphocytes/*immunology/pathology[MESH] |CD4-Positive T-Lymphocytes/immunology/pathology[MESH] |CD8-Positive T-Lymphocytes/immunology/pathology[MESH] |COVID-19/*immunology/pathology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin G/immunology[MESH] |Lymphocyte Count[MESH] |Male[MESH] |Middle Aged[MESH] |Monocytes/*immunology/pathology[MESH] |Prospective Studies[MESH] |SARS-CoV-2/*immunology[MESH]Increased B-cell activity with consumption of activated monocytes in s(epmc).pdf DeepDyve Pubget Overpricing