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10.1007/s40265-021-01488-z

http://scihub22266oqcxt.onion/10.1007/s40265-021-01488-z
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33788181!8010786!33788181
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suck abstract from ncbi

pmid33788181      Drugs 2021 ; 81 (5): 605-610
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  • Voclosporin: First Approval #MMPMID33788181
  • Heo YA
  • Drugs 2021[Apr]; 81 (5): 605-610 PMID33788181show ga
  • Voclosporin (Lupkynis()) is an oral calcineurin inhibitor immunosuppressant that is being developed by Aurinia Pharmaceuticals. In January 2021, based on positive results from the pivotal phases II and III trials, oral voclosporin received its first approval in the USA for use in combination with a background immunosuppressive therapy regimen for adults with active lupus nephritis. Voclosporin is also being explored for the novel coronavirus disease 2019 (COVID-19) in kidney transplant recipients. This article summarizes the milestones in the development of voclosporin leading to this first approval for lupus nephritis.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Kidney Transplantation[MESH]
  • |Animals[MESH]
  • |COVID-19/complications[MESH]
  • |Calcineurin Inhibitors/pharmacokinetics/pharmacology/*therapeutic use[MESH]
  • |Cyclosporine/pharmacokinetics/pharmacology/*therapeutic use[MESH]
  • |Drug Approval[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/pharmacokinetics/pharmacology/*therapeutic use[MESH]


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