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10.6061/clinics/2021/e2518 http://scihub22266oqcxt.onion/10.6061/clinics/2021/e2518 33787678!7955154!33787678     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clinics+(Sao+Paulo) 2021 ; 76 (ä): e2518 Nephropedia Template TP {{tp|p=33787678|t=2021. COVID-19 and Thromboinflammation: Is There a Role for Statins?|pdf=|usr=}}{{33787678}} gab.com Text COVID-19 and Thromboinflammation: Is There a Role for Statins JO: Clinics (Sao Paulo) http://www.kidney.de/pget.php?&tw=1&pmid=33787678 #FOAvip The novel coronavirus disease (COVID-19) showed increased morbidity and mortality rates and worse prognosis in individuals with underlying chronic diseases, especially cardiovascular disease and its risk factors, such as hypertension, diabetes, and obesity. There is also evidence of possible links among COVID-19, myocardial infarction, and stroke. Emerging evidence suggests a pro-inflammatory milieu and hypercoagulable state in patients with this infection. Despite anticoagulation, a large proportion of patients requiring intensive care may develop life-threatening thrombotic complications. Indeed, the levels of some markers of hemostatic activation, such as D-dimer, are commonly elevated in COVID-19, indicating potential risk of deep vein thrombosis and pulmonary thromboembolism. In this review, we critically examine and discuss aspects of hypercoagulability and inflammation in COVID-19 and the possible benefits of statins in this scenario, with emphasis on their underlying molecular mechanisms. Moreover, we present recommendations on the use of antiviral drugs in combination with statins. Twit Text FOAVip COVID-19 and Thromboinflammation: Is There a Role for Statins ????Clinics (Sao Paulo) http://www.kidney.de/pget.php?&tw=1&pmid=33787678 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33787678 #FOAvip English Wikipedia <ref>{{Cite pmid|33787678}}</ref> COVID-19 and Thromboinflammation: Is There a Role for Statins? #MMPMID33787678 Ferrari F; Martins VM; Teixeira M; Santos RD; Stein R Clinics (Sao Paulo) 2021[]; 76 (ä): e2518 PMID33787678show ga The novel coronavirus disease (COVID-19) showed increased morbidity and mortality rates and worse prognosis in individuals with underlying chronic diseases, especially cardiovascular disease and its risk factors, such as hypertension, diabetes, and obesity. There is also evidence of possible links among COVID-19, myocardial infarction, and stroke. Emerging evidence suggests a pro-inflammatory milieu and hypercoagulable state in patients with this infection. Despite anticoagulation, a large proportion of patients requiring intensive care may develop life-threatening thrombotic complications. Indeed, the levels of some markers of hemostatic activation, such as D-dimer, are commonly elevated in COVID-19, indicating potential risk of deep vein thrombosis and pulmonary thromboembolism. In this review, we critically examine and discuss aspects of hypercoagulability and inflammation in COVID-19 and the possible benefits of statins in this scenario, with emphasis on their underlying molecular mechanisms. Moreover, we present recommendations on the use of antiviral drugs in combination with statins. |*COVID-19[MESH] |*Coronavirus[MESH] |*Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects[MESH] |*Thrombosis[MESH] |Anticoagulants/adverse effects[MESH] |Humans[MESH] |Inflammation/drug therapy[MESH]COVID-19 and Thromboinflammation: Is There a Role for Statins?(epmc).pdf DeepDyve Pubget Overpricing