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10.22034/iji.2021.88780.1904 http://scihub22266oqcxt.onion/10.22034/iji.2021.88780.1904 33787515!ä!33787515 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Iran+J+Immunol 2021 ; 18 (1): 65-73 Nephropedia Template TP {{tp|p=33787515|t=2021. The relationship between serum levels of interleukin-2 and IL-8 with circulating microRNA-10b in patients with COVID-19 |pdf=|usr=}}{{33787515}} gab.com Text The relationship between serum levels of interleukin-2 and IL-8 with circulating microRNA-10b in patients with COVID-19 JO: Iran J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33787515 #FOAvip BACKGROUND: The role of cytokine storm in the immunopathogenesis of coronavirus disease 2019 (COVID-19) has been implicated. OBJECTIVE: To determine the association of microRNA (miRNA)-10b and serum levels of IL-2 and IL-8 in patients with COVID-19. METHODS: Blood samples were obtained from 33 COVID-19 patients and 29 healthy subjects. After RNA extraction and cDNA synthesis, the transcript level of miR-10b was determined by Real-time PCR. In addition, the serum levels of IL-2 and IL-8 were measured in subjects using ELISA. RESULTS: The patient group comprised of 33 patients with COVID-19 (62.4 +/- 3.7 years old), 13 (39%) males and 20 (61%) females. In the control group, 29 subjects (56.6 +/- 1.6 years old), 9 (31%) males and 20 (69%) females, were included. The expression of miR-10b was significantly downregulated in the peripheral blood of COVID-19 patients in comparison to the healthy controls (fold change= 0.12, P< 0.0001). The levels of IL-2 (P< 0.001) and IL-8 (P< 0.001) were significantly increased in the serum samples of COVID-19 patients compared to the healthy subjects. The expression level of miR-10b was correlated significantly with the serum levels of IL-2 and IL-8 as well as with the age of patients, ESR and CRP levels. CONCLUSIONS: miR-10b is downregulated in the COVID-19 patients and might result in increased levels of IL-2 and IL-8, hence contributing to cytokine storm. Twit Text FOAVip The relationship between serum levels of interleukin-2 and IL-8 with circulating microRNA-10b in patients with COVID-19 ????Iran J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33787515 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33787515 #FOAvip English Wikipedia <ref>{{Cite pmid|33787515}}</ref> The relationship between serum levels of interleukin-2 and IL-8 with circulating microRNA-10b in patients with COVID-19 #MMPMID33787515 Bagheri-Hosseinabadi Z; Ostad Ebrahimi H; Bahrehmand F; Taghipour G; Abbasifard M Iran J Immunol 2021[Mar]; 18 (1): 65-73 PMID33787515show ga BACKGROUND: The role of cytokine storm in the immunopathogenesis of coronavirus disease 2019 (COVID-19) has been implicated. OBJECTIVE: To determine the association of microRNA (miRNA)-10b and serum levels of IL-2 and IL-8 in patients with COVID-19. METHODS: Blood samples were obtained from 33 COVID-19 patients and 29 healthy subjects. After RNA extraction and cDNA synthesis, the transcript level of miR-10b was determined by Real-time PCR. In addition, the serum levels of IL-2 and IL-8 were measured in subjects using ELISA. RESULTS: The patient group comprised of 33 patients with COVID-19 (62.4 +/- 3.7 years old), 13 (39%) males and 20 (61%) females. In the control group, 29 subjects (56.6 +/- 1.6 years old), 9 (31%) males and 20 (69%) females, were included. The expression of miR-10b was significantly downregulated in the peripheral blood of COVID-19 patients in comparison to the healthy controls (fold change= 0.12, P< 0.0001). The levels of IL-2 (P< 0.001) and IL-8 (P< 0.001) were significantly increased in the serum samples of COVID-19 patients compared to the healthy subjects. The expression level of miR-10b was correlated significantly with the serum levels of IL-2 and IL-8 as well as with the age of patients, ESR and CRP levels. CONCLUSIONS: miR-10b is downregulated in the COVID-19 patients and might result in increased levels of IL-2 and IL-8, hence contributing to cytokine storm. |Aged[MESH] |Biomarkers/blood[MESH] |COVID-19/*blood/genetics/immunology/virology[MESH] |Case-Control Studies[MESH] |Circulating MicroRNA/*blood/genetics[MESH] |Cytokine Release Syndrome/blood/genetics/immunology/virology[MESH] |Female[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Interleukin-2/*blood[MESH] |Interleukin-8/*blood[MESH] |Male[MESH] |MicroRNAs/*blood/genetics[MESH] |Middle Aged[MESH]The relationship between serum levels of interleukin-2 and IL-8 with c(epmc).pdf DeepDyve Pubget Overpricing