On-Chip Optical Detection of Viruses: A Review #MMPMID33786535
Shi Y; Li Z; Liu PY; Nguyen BTT; Wu W; Zhao Q; Chin LK; Wei M; Yap PH; Zhou X; Zhao H; Yu D; Tsai DP; Liu AQ
Adv Photonics Res 2021[Apr]; 2 (4): 2000150 PMID33786535show ga
The current outbreak of the coronavirus disease-19 (COVID-19) pandemic worldwide has caused millions of fatalities and imposed a severe impact on our daily lives. Thus, the global healthcare system urgently calls for rapid, affordable, and reliable detection toolkits. Although the gold-standard nucleic acid amplification tests have been widely accepted and utilized, they are time-consuming and labor-intensive, which exceedingly hinder the mass detection in low-income populations, especially in developing countries. Recently, due to the blooming development of photonics, various optical chips have been developed to detect single viruses with the advantages of fast, label-free, affordable, and point of care deployment. Herein, optical approaches especially in three perspectives, e.g., flow-free optical methods, optofluidics, and surface-modification-assisted approaches, are summarized. The future development of on-chip optical-detection methods in the wave of emerging new ideas in nanophotonics is also briefly discussed.
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Adv+Photonics+Res 2021 ; 2 (4): 2000150
