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10.1038/s41598-021-86679-0 http://scihub22266oqcxt.onion/10.1038/s41598-021-86679-0 33785846!8010049!33785846     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2021 ; 11 (1): 7132 Nephropedia Template TP {{tp|p=33785846|t=2021. Ivermectin reduces in vivo coronavirus infection in a mouse experimental model |pdf=|usr=}}{{33785846}} gab.com Text Ivermectin reduces in vivo coronavirus infection in a mouse experimental model JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33785846 #FOAvip The objective of this study was to test the effectiveness of ivermectin for the treatment of mouse hepatitis virus (MHV), a type 2 family RNA coronavirus similar to SARS-CoV-2. Female BALB/cJ mice were infected with 6,000 PFU of MHV-A59 (group infected, n = 20) or infected and then immediately treated with a single dose of 500 microg/kg ivermectin (group infected + IVM, n = 20) or were not infected and treated with PBS (control group, n = 16). Five days after infection/treatment, the mice were euthanized and the tissues were sampled to assess their general health status and infection levels. Overall, the results demonstrated that viral infection induced typical MHV-caused disease, with the livers showing severe hepatocellular necrosis surrounded by a severe lymphoplasmacytic inflammatory infiltration associated with a high hepatic viral load (52,158 AU), while mice treated with ivermectin showed a better health status with a lower viral load (23,192 AU; p < 0.05), with only a few having histopathological liver damage (p < 0.05). No significant differences were found between the group infected + IVM and control group mice (P = NS). Furthermore, serum transaminase levels (aspartate aminotransferase and alanine aminotransferase) were significantly lower in the treated mice than in the infected animals. In conclusion, ivermectin diminished the MHV viral load and disease in the mice, being a useful model for further understanding this therapy against coronavirus diseases. Twit Text FOAVip Ivermectin reduces in vivo coronavirus infection in a mouse experimental model ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33785846 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33785846 #FOAvip English Wikipedia <ref>{{Cite pmid|33785846}}</ref> Ivermectin reduces in vivo coronavirus infection in a mouse experimental model #MMPMID33785846 Arevalo AP; Pagotto R; Porfido JL; Daghero H; Segovia M; Yamasaki K; Varela B; Hill M; Verdes JM; Duhalde Vega M; Bollati-Fogolin M; Crispo M Sci Rep 2021[Mar]; 11 (1): 7132 PMID33785846show ga The objective of this study was to test the effectiveness of ivermectin for the treatment of mouse hepatitis virus (MHV), a type 2 family RNA coronavirus similar to SARS-CoV-2. Female BALB/cJ mice were infected with 6,000 PFU of MHV-A59 (group infected, n = 20) or infected and then immediately treated with a single dose of 500 microg/kg ivermectin (group infected + IVM, n = 20) or were not infected and treated with PBS (control group, n = 16). Five days after infection/treatment, the mice were euthanized and the tissues were sampled to assess their general health status and infection levels. Overall, the results demonstrated that viral infection induced typical MHV-caused disease, with the livers showing severe hepatocellular necrosis surrounded by a severe lymphoplasmacytic inflammatory infiltration associated with a high hepatic viral load (52,158 AU), while mice treated with ivermectin showed a better health status with a lower viral load (23,192 AU; p < 0.05), with only a few having histopathological liver damage (p < 0.05). No significant differences were found between the group infected + IVM and control group mice (P = NS). Furthermore, serum transaminase levels (aspartate aminotransferase and alanine aminotransferase) were significantly lower in the treated mice than in the infected animals. In conclusion, ivermectin diminished the MHV viral load and disease in the mice, being a useful model for further understanding this therapy against coronavirus diseases. |Animals[MESH] |Antiviral Agents/administration & dosage/*pharmacology[MESH] |Body Weight/drug effects[MESH] |Coronavirus Infections/*drug therapy/pathology/virology[MESH] |Disease Models, Animal[MESH] |Female[MESH] |Ivermectin/administration & dosage/*pharmacology[MESH] |Kidney/drug effects/metabolism[MESH] |Liver/drug effects/metabolism/pathology/virology[MESH] |Mice[MESH] |Mice, Inbred BALB C[MESH] |Monocytes/drug effects[MESH] |Murine hepatitis virus/pathogenicity[MESH] |Neutrophils/drug effects[MESH] |Proteins/metabolism[MESH] |Transaminases/metabolism[MESH] |Tumor Necrosis Factor-alpha/blood[MESH]Ivermectin reduces in vivo coronavirus infection in a mouse experiment(epmc).pdf DeepDyve Pubget Overpricing