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10.1038/s41467-021-22210-3 http://scihub22266oqcxt.onion/10.1038/s41467-021-22210-3 33785765!8010106!33785765     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2021 ; 12 (1): 1961 Nephropedia Template TP {{tp|p=33785765|t=2021. SARS-CoV-2 in severe COVID-19 induces a TGF-beta-dominated chronic immune response that does not target itself |pdf=|usr=}}{{33785765}} gab.com Text SARS-CoV-2 in severe COVID-19 induces a TGF-beta-dominated chronic immune response that does not target itself JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33785765 #FOAvip The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study the dynamics of adaptive immune response in COVID-19 patients requiring intensive care. Before seroconversion in response to SARS-CoV-2 spike protein, peripheral plasmablasts display a type 1 interferon-induced gene expression signature; however, following seroconversion, plasmablasts lose this signature, express instead gene signatures induced by IL-21 and TGF-beta, and produce mostly IgG1 and IgA1. In the sustained immune reaction from COVID-19 patients, plasmablasts shift to the expression of IgA2, thereby reflecting an instruction by TGF-beta. Despite their continued presence in the blood, plasmablasts are not found in the lungs of deceased COVID-19 patients, nor does patient IgA2 binds to the dominant antigens of SARS-CoV-2. Our results thus suggest that, in severe COVID-19, SARS-CoV-2 triggers a chronic immune reaction that is instructed by TGF-beta, and is distracted from itself. Twit Text FOAVip SARS-CoV-2 in severe COVID-19 induces a TGF-beta-dominated chronic immune response that does not target itself ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=33785765 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33785765 #FOAvip English Wikipedia <ref>{{Cite pmid|33785765}}</ref> SARS-CoV-2 in severe COVID-19 induces a TGF-beta-dominated chronic immune response that does not target itself #MMPMID33785765 Ferreira-Gomes M; Kruglov A; Durek P; Heinrich F; Tizian C; Heinz GA; Pascual-Reguant A; Du W; Mothes R; Fan C; Frischbutter S; Habenicht K; Budzinski L; Ninnemann J; Jani PK; Guerra GM; Lehmann K; Matz M; Ostendorf L; Heiberger L; Chang HD; Bauherr S; Maurer M; Schonrich G; Raftery M; Kallinich T; Mall MA; Angermair S; Treskatsch S; Dorner T; Corman VM; Diefenbach A; Volk HD; Elezkurtaj S; Winkler TH; Dong J; Hauser AE; Radbruch H; Witkowski M; Melchers F; Radbruch A; Mashreghi MF Nat Commun 2021[Mar]; 12 (1): 1961 PMID33785765show ga The pathogenesis of severe COVID-19 reflects an inefficient immune reaction to SARS-CoV-2. Here we analyze, at the single cell level, plasmablasts egressed into the blood to study the dynamics of adaptive immune response in COVID-19 patients requiring intensive care. Before seroconversion in response to SARS-CoV-2 spike protein, peripheral plasmablasts display a type 1 interferon-induced gene expression signature; however, following seroconversion, plasmablasts lose this signature, express instead gene signatures induced by IL-21 and TGF-beta, and produce mostly IgG1 and IgA1. In the sustained immune reaction from COVID-19 patients, plasmablasts shift to the expression of IgA2, thereby reflecting an instruction by TGF-beta. Despite their continued presence in the blood, plasmablasts are not found in the lungs of deceased COVID-19 patients, nor does patient IgA2 binds to the dominant antigens of SARS-CoV-2. Our results thus suggest that, in severe COVID-19, SARS-CoV-2 triggers a chronic immune reaction that is instructed by TGF-beta, and is distracted from itself. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/*immunology/virology[MESH] |Female[MESH] |Humans[MESH] |Immunoglobulin A/immunology[MESH] |Immunoglobulin G/immunology[MESH] |Interleukins/immunology[MESH] |Male[MESH] |Middle Aged[MESH] |Plasma Cells/immunology[MESH] |SARS-CoV-2/genetics/*immunology[MESH] |Spike Glycoprotein, Coronavirus/genetics/immunology[MESH]SARS-CoV-2 in severe COVID-19 induces a TGF-beta-dominated chronic imm(epmc).pdf DeepDyve Pubget Overpricing