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10.1016/j.ijid.2021.03.068 http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.03.068 33785459!7997945!33785459     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2021 ; 106 (ä): 228-236 Nephropedia Template TP {{tp|p=33785459|t=2021. Emergence and outcomes of the SARS-CoV-2 Marseille-4 variant |pdf=|usr=}}{{33785459}} gab.com Text Emergence and outcomes of the SARS-CoV-2 Marseille-4 variant JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33785459 #FOAvip BACKGROUND: In Marseille, France, following a first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in March-May 2020, a second epidemic phase occurred from June, involving 10 new variants. The Marseille-4 variant caused an epidemic that started in August and is still ongoing. METHODS: The 1038 SARS-CoV-2 whole genome sequences obtained in our laboratory by next-generation sequencing with Illumina technology were analysed using Nextclade and nextstrain/ncov pipelines and IQ-TREE. A Marseille-4-specific qPCR assay was implemented. Demographic and clinical features were compared between patients with the Marseille-4 variant and those with earlier strains. RESULTS: Marseille-4 harbours 13 hallmark mutations. One leads to an S477N substitution in the receptor binding domain of the spike protein targeted by current vaccines. Using a specific qPCR, it was observed that Marseille-4 caused 12-100% of SARS-CoV-2 infections in Marseille from September 2020, being involved in 2106 diagnoses. This variant was more frequently associated with hypoxemia than were clade 20A strains before May 2020. It caused a re-infection in 11 patients diagnosed with different SARS-CoV-2 strains before June 2020, suggesting either short-term protective immunity or a lack of cross-immunity. CONCLUSIONS: Marseille-4 should be considered as a major SARS-CoV-2 variant. Its sudden appearance points towards an animal reservoir, possibly mink. The protective role of past exposure and current vaccines against this variant should be evaluated. Twit Text FOAVip Emergence and outcomes of the SARS-CoV-2 Marseille-4 variant ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33785459 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33785459 #FOAvip English Wikipedia <ref>{{Cite pmid|33785459}}</ref> Emergence and outcomes of the SARS-CoV-2 Marseille-4 variant #MMPMID33785459 Fournier PE; Colson P; Levasseur A; Devaux CA; Gautret P; Bedotto M; Delerce J; Brechard L; Pinault L; Lagier JC; Fenollar F; Raoult D Int J Infect Dis 2021[May]; 106 (ä): 228-236 PMID33785459show ga BACKGROUND: In Marseille, France, following a first severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in March-May 2020, a second epidemic phase occurred from June, involving 10 new variants. The Marseille-4 variant caused an epidemic that started in August and is still ongoing. METHODS: The 1038 SARS-CoV-2 whole genome sequences obtained in our laboratory by next-generation sequencing with Illumina technology were analysed using Nextclade and nextstrain/ncov pipelines and IQ-TREE. A Marseille-4-specific qPCR assay was implemented. Demographic and clinical features were compared between patients with the Marseille-4 variant and those with earlier strains. RESULTS: Marseille-4 harbours 13 hallmark mutations. One leads to an S477N substitution in the receptor binding domain of the spike protein targeted by current vaccines. Using a specific qPCR, it was observed that Marseille-4 caused 12-100% of SARS-CoV-2 infections in Marseille from September 2020, being involved in 2106 diagnoses. This variant was more frequently associated with hypoxemia than were clade 20A strains before May 2020. It caused a re-infection in 11 patients diagnosed with different SARS-CoV-2 strains before June 2020, suggesting either short-term protective immunity or a lack of cross-immunity. CONCLUSIONS: Marseille-4 should be considered as a major SARS-CoV-2 variant. Its sudden appearance points towards an animal reservoir, possibly mink. The protective role of past exposure and current vaccines against this variant should be evaluated. |*Genome, Viral[MESH] |*Mutation[MESH] |*Whole Genome Sequencing[MESH] |Animals[MESH] |COVID-19/*genetics/virology[MESH] |Epidemics[MESH] |France/epidemiology[MESH] |Humans[MESH] |Mink/virology[MESH] |Molecular Epidemiology[MESH] |Phylogeny[MESH] |Reinfection/virology[MESH]Emergence and outcomes of the SARS-CoV-2 Marseille-4 variant (epmc).pdf DeepDyve Pubget Overpricing