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10.1371/journal.pone.0249421

http://scihub22266oqcxt.onion/10.1371/journal.pone.0249421
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33784355!8009384!33784355
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suck abstract from ncbi


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pmid33784355      PLoS+One 2021 ; 16 (3): e0249421
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  • Thyroid function analysis in COVID-19: A retrospective study from a single center #MMPMID33784355
  • Malik J; Malik A; Javaid M; Zahid T; Ishaq U; Shoaib M
  • PLoS One 2021[]; 16 (3): e0249421 PMID33784355show ga
  • BACKGROUND AND OBJECTIVE: Coronavirus disease 2019 (COVID-19) is an on-going epidemic with a multitude of long-ranging effects on the physiological balance of the human body. It can cause several effects on thyroid functions as well. We aimed to assess the lasting sequelae of COVID-19 on thyroid hormone and the clinical course of the disease as a result. METHODS: Out of 76 patients, 48 patients of COVID-19 positive and 28 patients of COVID-19 negative polymerase chain reaction (PCR) were assessed for thyroid functions, IL-6, and Procalcitonin between moderate, severe, and critical pneumonia on HRCT. RESULTS: Seventy-five percent of patients with COVID-19 had thyroid abnormalities and higher IL-6 levels (76.10 +/- 82.35 vs. 6.99 +/- 3.99, 95% CI 52.18-100.01, P-value <0.01). Logistic regression analysis suggested TT3 (P-value 0.01), IL-6 (P-value <0.01), and Procalcitonin (P-value 0.03) as independent risk factors for COVID-19. ROC curve demonstrated IL-6 as the most sensitive marker (P-value <0.01), and TT3, and Procalcitonin as the predictor for COVID-19 disease. CONCLUSION: This pilot study from Pakistan demonstrates that changes in serum TSH and TT3 levels may be important manifestations of the courses of COVID-19 pneumonia.
  • |COVID-19/epidemiology/*physiopathology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |Pilot Projects[MESH]
  • |Retrospective Studies[MESH]


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