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10.1021/jacs.1c01914 http://scihub22266oqcxt.onion/10.1021/jacs.1c01914 33783202!8154514!33783202     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Chem+Soc 2021 ; 143 (13): 4942-4948 Nephropedia Template TP {{tp|p=33783202|t=2021. 3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs |pdf=|usr=}}{{33783202}} gab.com Text 3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=33783202 #FOAvip Multidimensional NOESY experiments targeting correlations between exchangeable imino and amino protons provide valuable information about base pairing in nucleic acids. It has been recently shown that the sensitivity of homonuclear correlations involving RNA's labile imino protons can be significantly enhanced, by exploiting the repolarization brought about by solvent exchanges. Homonuclear correlations, however, are of limited spectral resolution, and usually incapable of tackling relatively large homopolymers with repeating structures like RNAs. This study presents a heteronuclear-resolved version of those NOESY experiments, in which magnetization transfers between the aqueous solvent and the nucleic acid protons are controlled by selecting specific chemical shift combinations of a coupled (1)H-(15)N spin pair. This selective control effectively leads to a pseudo-3D version of HSQC-NOESY, but with cross-peaks enhanced by approximately 2-5x as compared with conventional 2D NOESY counterparts. The enhanced signal sensitivity as well as access to both (15)N-(1)H and (1)H-(1)H NOESY dimensions can greatly facilitate RNA assignments and secondary structure determinations, as demonstrated here with the analysis of genome fragments derived from the SARS-CoV-2 virus. Twit Text FOAVip 3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=33783202 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33783202 #FOAvip English Wikipedia <ref>{{Cite pmid|33783202}}</ref> 3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs #MMPMID33783202 Kim J; Novakovic M; Jayanthi S; Lupulescu A; Kupce E; Grun JT; Mertinkus K; Oxenfarth A; Richter C; Schnieders R; Wirmer-Bartoschek J; Schwalbe H; Frydman L J Am Chem Soc 2021[Apr]; 143 (13): 4942-4948 PMID33783202show ga Multidimensional NOESY experiments targeting correlations between exchangeable imino and amino protons provide valuable information about base pairing in nucleic acids. It has been recently shown that the sensitivity of homonuclear correlations involving RNA's labile imino protons can be significantly enhanced, by exploiting the repolarization brought about by solvent exchanges. Homonuclear correlations, however, are of limited spectral resolution, and usually incapable of tackling relatively large homopolymers with repeating structures like RNAs. This study presents a heteronuclear-resolved version of those NOESY experiments, in which magnetization transfers between the aqueous solvent and the nucleic acid protons are controlled by selecting specific chemical shift combinations of a coupled (1)H-(15)N spin pair. This selective control effectively leads to a pseudo-3D version of HSQC-NOESY, but with cross-peaks enhanced by approximately 2-5x as compared with conventional 2D NOESY counterparts. The enhanced signal sensitivity as well as access to both (15)N-(1)H and (1)H-(1)H NOESY dimensions can greatly facilitate RNA assignments and secondary structure determinations, as demonstrated here with the analysis of genome fragments derived from the SARS-CoV-2 virus. |*Magnetic Phenomena[MESH] |*Magnetic Resonance Spectroscopy[MESH] |RNA, Viral/*chemistry[MESH] |SARS-CoV-2/*genetics[MESH]3D Heteronuclear Magnetization Transfers for the Establishment of Seco(epmc).pdf DeepDyve Pubget Overpricing