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10.4049/jimmunol.2001428 http://scihub22266oqcxt.onion/10.4049/jimmunol.2001428 33782089!8183577!33782089     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2021 ; 206 (8): 1691-1696 Nephropedia Template TP {{tp|p=33782089|t=2021. Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease |pdf=|usr=}}{{33782089}} gab.com Text Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33782089 #FOAvip Severe COVID-19 disease is associated with elevated inflammatory responses. One form of Aicardi-Goutieres syndrome caused by inactivating mutations in ADAR results in reduced adenosine-to-inosine (A-to-I) editing of endogenous dsRNAs, induction of IFNs, IFN-stimulated genes, other inflammatory mediators, morbidity, and mortality. Alu elements, approximately 10% of the human genome, are the most common A-to-I-editing sites. Using leukocyte whole-genome RNA-sequencing data, we found reduced A-to-I editing of Alu dsRNAs in patients with severe COVID-19 disease. Dendritic cells infected with COVID-19 also exhibit reduced A-to-I editing of Alu dsRNAs. Unedited Alu dsRNAs, but not edited Alu dsRNAs, are potent inducers of IRF and NF-kappaB transcriptional responses, IL6, IL8, and IFN-stimulated genes. Thus, decreased A-to-I editing that may lead to accumulation of unedited Alu dsRNAs and increased inflammatory responses is associated with severe COVID-19 disease. Twit Text FOAVip Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33782089 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33782089 #FOAvip English Wikipedia <ref>{{Cite pmid|33782089}}</ref> Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease #MMPMID33782089 Crooke PS 3rd; Tossberg JT; Porter KP; Aune TM J Immunol 2021[Apr]; 206 (8): 1691-1696 PMID33782089show ga Severe COVID-19 disease is associated with elevated inflammatory responses. One form of Aicardi-Goutieres syndrome caused by inactivating mutations in ADAR results in reduced adenosine-to-inosine (A-to-I) editing of endogenous dsRNAs, induction of IFNs, IFN-stimulated genes, other inflammatory mediators, morbidity, and mortality. Alu elements, approximately 10% of the human genome, are the most common A-to-I-editing sites. Using leukocyte whole-genome RNA-sequencing data, we found reduced A-to-I editing of Alu dsRNAs in patients with severe COVID-19 disease. Dendritic cells infected with COVID-19 also exhibit reduced A-to-I editing of Alu dsRNAs. Unedited Alu dsRNAs, but not edited Alu dsRNAs, are potent inducers of IRF and NF-kappaB transcriptional responses, IL6, IL8, and IFN-stimulated genes. Thus, decreased A-to-I editing that may lead to accumulation of unedited Alu dsRNAs and increased inflammatory responses is associated with severe COVID-19 disease. |*SARS-CoV-2[MESH] |*Severity of Illness Index[MESH] |Adenosine/*genetics/metabolism[MESH] |Alu Elements/*genetics[MESH] |COVID-19/*genetics/pathology[MESH] |Dendritic Cells/metabolism/virology[MESH] |Genome, Human[MESH] |Humans[MESH] |Inosine/*genetics/metabolism[MESH] |Interferon Regulatory Factors/metabolism[MESH] |NF-kappa B/metabolism[MESH] |RNA Editing/*genetics[MESH] |RNA, Double-Stranded/*genetics[MESH] |RNA-Seq[MESH]Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu R(epmc).pdf DeepDyve Pubget Overpricing