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10.1136/thoraxjnl-2020-216512 http://scihub22266oqcxt.onion/10.1136/thoraxjnl-2020-216512 33782080!8011425!33782080     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thorax 2021 ; 76 (9): 860-866 Nephropedia Template TP {{tp|p=33782080|t=2021. Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care data |pdf=|usr=}}{{33782080}} gab.com Text Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care data JO: Thorax http://www.kidney.de/pget.php?&tw=1&pmid=33782080 #FOAvip BACKGROUND: The impact of COVID-19 and ensuing national lockdown on asthma exacerbations is unclear. METHODS: We conducted an interrupted time-series (lockdown on 23 March 2020 as point of interruption) analysis in asthma cohort identified using a validated algorithm from a national-level primary care database, the Optimum Patient Care Database. We derived asthma exacerbation rates for every week and compared exacerbation rates in the period: January to August 2020 with a pre-COVID-19 period and January to August 2016-2019. Exacerbations were defined as asthma-related hospital attendance/admission (including accident and emergency visit), or an acute course of oral corticosteroids with evidence of respiratory review, as recorded in primary care. We used a generalised least squares modelling approach and stratified the analyses by age, sex, English region and healthcare setting. RESULTS: From a database of 9 949 387 patients, there were 100 165 patients with asthma who experienced at least one exacerbation during 2016-2020. Of 278 996 exacerbation episodes, 49 938 (17.9%) required hospital visit. Comparing pre-lockdown to post-lockdown period, we observed a statistically significant reduction in the level (-0.196 episodes per person-year; p<0.001; almost 20 episodes for every 100 patients with asthma per year) of exacerbation rates across all patients. The reductions in level in stratified analyses were: 0.005-0.244 (healthcare setting, only those without hospital attendance/admission were significant), 0.210-0.277 (sex), 0.159-0.367 (age), 0.068-0.590 (region). CONCLUSIONS: There has been a significant reduction in attendance to primary care for asthma exacerbations during the pandemic. This reduction was observed in all age groups, both sexes and across most regions in England. Twit Text FOAVip Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care data ????Thorax http://www.kidney.de/pget.php?&tw=1&pmid=33782080 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33782080 #FOAvip English Wikipedia <ref>{{Cite pmid|33782080}}</ref> Impact of COVID-19 national lockdown on asthma exacerbations: interrupted time-series analysis of English primary care data #MMPMID33782080 Shah SA; Quint JK; Nwaru BI; Sheikh A Thorax 2021[Sep]; 76 (9): 860-866 PMID33782080show ga BACKGROUND: The impact of COVID-19 and ensuing national lockdown on asthma exacerbations is unclear. METHODS: We conducted an interrupted time-series (lockdown on 23 March 2020 as point of interruption) analysis in asthma cohort identified using a validated algorithm from a national-level primary care database, the Optimum Patient Care Database. We derived asthma exacerbation rates for every week and compared exacerbation rates in the period: January to August 2020 with a pre-COVID-19 period and January to August 2016-2019. Exacerbations were defined as asthma-related hospital attendance/admission (including accident and emergency visit), or an acute course of oral corticosteroids with evidence of respiratory review, as recorded in primary care. We used a generalised least squares modelling approach and stratified the analyses by age, sex, English region and healthcare setting. RESULTS: From a database of 9 949 387 patients, there were 100 165 patients with asthma who experienced at least one exacerbation during 2016-2020. Of 278 996 exacerbation episodes, 49 938 (17.9%) required hospital visit. Comparing pre-lockdown to post-lockdown period, we observed a statistically significant reduction in the level (-0.196 episodes per person-year; p<0.001; almost 20 episodes for every 100 patients with asthma per year) of exacerbation rates across all patients. The reductions in level in stratified analyses were: 0.005-0.244 (healthcare setting, only those without hospital attendance/admission were significant), 0.210-0.277 (sex), 0.159-0.367 (age), 0.068-0.590 (region). CONCLUSIONS: There has been a significant reduction in attendance to primary care for asthma exacerbations during the pandemic. This reduction was observed in all age groups, both sexes and across most regions in England. |*Disease Progression[MESH] |*Symptom Flare Up[MESH] |Administration, Oral[MESH] |Adolescent[MESH] |Adrenal Cortex Hormones/therapeutic use[MESH] |Adult[MESH] |Asthma/drug therapy/*epidemiology[MESH] |COVID-19/*prevention & control[MESH] |Emergency Service, Hospital/statistics & numerical data[MESH] |England/epidemiology[MESH] |Female[MESH] |Humans[MESH] |Interrupted Time Series Analysis[MESH] |Male[MESH] |Middle Aged[MESH] |Patient Admission/statistics & numerical data[MESH] |Primary Health Care/*statistics & numerical data[MESH] |SARS-CoV-2[MESH]Impact of COVID-19 national lockdown on asthma exacerbations: interrup(epmc).pdf DeepDyve Pubget Overpricing