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10.1016/j.ijid.2021.03.066 http://scihub22266oqcxt.onion/10.1016/j.ijid.2021.03.066 33781906!7997692!33781906     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Infect+Dis 2021 ; 106 (ä): 155-159 Nephropedia Template TP {{tp|p=33781906|t=2021. Circulating activated neutrophils in COVID-19: An independent predictor for mechanical ventilation and death |pdf=|usr=}}{{33781906}} gab.com Text Circulating activated neutrophils in COVID-19: An independent predictor for mechanical ventilation and death JO: Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33781906 #FOAvip OBJECTIVES: Critical illness in COVID-19 is attributed to an exaggerated host immune response. Since neutrophils are the major component of innate immunity, we hypothesize that the quantum of activated neutrophils in the blood may predict an adverse outcome. DESIGN: In a retrospective study of 300 adult patients with confirmed COVID-19, we analyzed the impact of neutrophil activation (NEUT-RI), interleukin-6 (IL-6) and the established clinical risk factors of age, diabetes, obesity and hypertension on the clinical outcome. RESULTS: Significant predictors of the need for mechanical ventilation were NEUT-RI (Odds Ratio (OR) = 1.22, P < 0.001), diabetes (OR = 2.56, P = 0.00846) and obesity (OR = 6.55, P < 0.001). For death, the significant predictors were NEUT-RI (OR = 1.14, P = 0.00432), diabetes (OR = 4.11, P = 0.00185) and age (OR = 1.04, P = 0.00896). The optimal cut-off value for NEUT-RI to predict mechanical ventilation and death was 52 fluorescence intensity units (sensitivity 44%, specificity 88%, area under the curve 0.67 and 44%, 86%, 0.64, respectively). CONCLUSION: This finding supports an aberrant neutrophil response in COVID-19, likely due to uncontained viral replication, tissue hypoxia and exacerbated inflammation, introduces a novel biomarker for rapid monitoring and opens new avenues for therapeutic strategies. Twit Text FOAVip Circulating activated neutrophils in COVID-19: An independent predictor for mechanical ventilation and death ????Int J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=33781906 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33781906 #FOAvip English Wikipedia <ref>{{Cite pmid|33781906}}</ref> Circulating activated neutrophils in COVID-19: An independent predictor for mechanical ventilation and death #MMPMID33781906 Dennison D; Al Khabori M; Al Mamari S; Aurelio A; Al Hinai H; Al Maamari K; Alshekaili J; Al Khadouri G Int J Infect Dis 2021[May]; 106 (ä): 155-159 PMID33781906show ga OBJECTIVES: Critical illness in COVID-19 is attributed to an exaggerated host immune response. Since neutrophils are the major component of innate immunity, we hypothesize that the quantum of activated neutrophils in the blood may predict an adverse outcome. DESIGN: In a retrospective study of 300 adult patients with confirmed COVID-19, we analyzed the impact of neutrophil activation (NEUT-RI), interleukin-6 (IL-6) and the established clinical risk factors of age, diabetes, obesity and hypertension on the clinical outcome. RESULTS: Significant predictors of the need for mechanical ventilation were NEUT-RI (Odds Ratio (OR) = 1.22, P < 0.001), diabetes (OR = 2.56, P = 0.00846) and obesity (OR = 6.55, P < 0.001). For death, the significant predictors were NEUT-RI (OR = 1.14, P = 0.00432), diabetes (OR = 4.11, P = 0.00185) and age (OR = 1.04, P = 0.00896). The optimal cut-off value for NEUT-RI to predict mechanical ventilation and death was 52 fluorescence intensity units (sensitivity 44%, specificity 88%, area under the curve 0.67 and 44%, 86%, 0.64, respectively). CONCLUSION: This finding supports an aberrant neutrophil response in COVID-19, likely due to uncontained viral replication, tissue hypoxia and exacerbated inflammation, introduces a novel biomarker for rapid monitoring and opens new avenues for therapeutic strategies. |*Neutrophil Activation[MESH] |Adult[MESH] |Biomarkers/blood[MESH] |COVID-19/*immunology/*physiopathology[MESH] |Death[MESH] |Female[MESH] |Flow Cytometry/instrumentation[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Inflammation/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Neutrophils/*immunology/*pathology[MESH] |Optical Imaging/instrumentation[MESH] |Respiration, Artificial[MESH] |Retrospective Studies[MESH] |Risk Factors[MESH]Circulating activated neutrophils in COVID-19: An independent predicto(epmc).pdf DeepDyve Pubget Overpricing