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10.1016/j.lfs.2021.119376 http://scihub22266oqcxt.onion/10.1016/j.lfs.2021.119376 33781826!7997864!33781826     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Life+Sci 2021 ; 276 (ä): 119376 Nephropedia Template TP {{tp|p=33781826|t=2021. Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients |pdf=|usr=}}{{33781826}} gab.com Text Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients JO: Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33781826 #FOAvip The severe forms and worsened outcomes of COVID-19 (coronavirus disease 19) are closely associated with hypertension and cardiovascular disease. Endothelial cells express Angiotensin-Converting Enzyme 2 (ACE2), which is the entrance door for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The hallmarks of severe illness caused by SARS-CoV-2 infection are increased levels of IL-6, C-reactive protein, D-dimer, ferritin, neutrophilia and lymphopenia, pulmonary intravascular coagulopathy and microthrombi of alveolar capillaries. The endothelial glycocalyx, a proteoglycan- and glycoprotein-rich layer covering the luminal side of endothelial cells, contributes to vascular homeostasis. It regulates vascular tonus and permeability, prevents thrombosis, and modulates leukocyte adhesion and inflammatory response. We hypothesized that cytokine production and reactive oxygen species (ROS) generation associated with COVID-19 leads to glycocalyx degradation. A cohort of 20 hospitalized patients with a confirmed COVID-19 diagnosis and healthy subjects were enrolled in this study. Mechanisms associated with glycocalyx degradation in COVID-19 were investigated. Increased plasma concentrations of IL-6 and IL1-beta, as well as increased lipid peroxidation and glycocalyx components were detected in plasma from COVID-19 patients compared to plasma from healthy subjects. Plasma from COVID-19 patients induced glycocalyx shedding in cultured human umbilical vein endothelial cells (HUVECs) and disrupted redox balance. Treatment of HUVECs with low molecular weight heparin inhibited the glycocalyx perturbation. In conclusion, plasma from COVID-19 patients promotes glycocalyx shedding and redox imbalance in endothelial cells, and heparin treatment potentially inhibits glycocalyx disruption. Twit Text FOAVip Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients ????Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=33781826 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33781826 #FOAvip English Wikipedia <ref>{{Cite pmid|33781826}}</ref> Heparin prevents in vitro glycocalyx shedding induced by plasma from COVID-19 patients #MMPMID33781826 Potje SR; Costa TJ; Fraga-Silva TFC; Martins RB; Benatti MN; Almado CEL; de Sa KSG; Bonato VLD; Arruda E; Louzada-Junior P; Oliveira RDR; Zamboni DS; Becari C; Auxiliadora-Martins M; Tostes RC Life Sci 2021[Jul]; 276 (ä): 119376 PMID33781826show ga The severe forms and worsened outcomes of COVID-19 (coronavirus disease 19) are closely associated with hypertension and cardiovascular disease. Endothelial cells express Angiotensin-Converting Enzyme 2 (ACE2), which is the entrance door for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The hallmarks of severe illness caused by SARS-CoV-2 infection are increased levels of IL-6, C-reactive protein, D-dimer, ferritin, neutrophilia and lymphopenia, pulmonary intravascular coagulopathy and microthrombi of alveolar capillaries. The endothelial glycocalyx, a proteoglycan- and glycoprotein-rich layer covering the luminal side of endothelial cells, contributes to vascular homeostasis. It regulates vascular tonus and permeability, prevents thrombosis, and modulates leukocyte adhesion and inflammatory response. We hypothesized that cytokine production and reactive oxygen species (ROS) generation associated with COVID-19 leads to glycocalyx degradation. A cohort of 20 hospitalized patients with a confirmed COVID-19 diagnosis and healthy subjects were enrolled in this study. Mechanisms associated with glycocalyx degradation in COVID-19 were investigated. Increased plasma concentrations of IL-6 and IL1-beta, as well as increased lipid peroxidation and glycocalyx components were detected in plasma from COVID-19 patients compared to plasma from healthy subjects. Plasma from COVID-19 patients induced glycocalyx shedding in cultured human umbilical vein endothelial cells (HUVECs) and disrupted redox balance. Treatment of HUVECs with low molecular weight heparin inhibited the glycocalyx perturbation. In conclusion, plasma from COVID-19 patients promotes glycocalyx shedding and redox imbalance in endothelial cells, and heparin treatment potentially inhibits glycocalyx disruption. |Aged[MESH] |Blood Coagulation Disorders/blood/virology[MESH] |COVID-19 Testing[MESH] |COVID-19/*blood/metabolism/*pathology[MESH] |Case-Control Studies[MESH] |Cell Adhesion/physiology[MESH] |Endothelium, Vascular/metabolism[MESH] |Female[MESH] |Glycocalyx/metabolism/*pathology/virology[MESH] |Heparin/*pharmacology[MESH] |Human Umbilical Vein Endothelial Cells[MESH] |Humans[MESH] |Interleukin-1beta/blood[MESH] |Interleukin-6/blood[MESH] |Male[MESH] |Middle Aged[MESH] |Oxidation-Reduction[MESH] |SARS-CoV-2[MESH]Heparin prevents in vitro glycocalyx shedding induced by plasma from C(epmc).pdf DeepDyve Pubget Overpricing