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10.1080/14787210.2021.1909476

http://scihub22266oqcxt.onion/10.1080/14787210.2021.1909476
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suck abstract from ncbi


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pmid33781166      Expert+Rev+Anti+Infect+Ther 2021 ; 19 (10): 1331-1339
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  • System for administering and monitoring hydroxychloroquine prophylaxis for COVID-19 in accordance with a national advisory: preliminary experience of a tertiary care institute in India #MMPMID33781166
  • Kumar-M P; Mohindra R; Bhalla A; Shafiq N; Suri V; Kumari D; Pandey AK; Gupta A; Gupta PC; Patil A; Kakkar AK; Malhotra S
  • Expert Rev Anti Infect Ther 2021[Oct]; 19 (10): 1331-1339 PMID33781166show ga
  • BACKGROUND: Hydroxychloroquine (HCQ) was one of the earliest drugs to be recommended for tackling the COVID-19 threat leading to its widespread usage. We provide preliminary findings of the system, established in a tertiary care academic center for the administration of HCQ prophylaxis to healthcare workers (HCW) based on Indian Council of Medical Research (ICMR) advisory. METHODS: A dedicated clinical pharmacology and internal medicine team screened for contraindications, administered informed consent, maintained compliance and monitored for adverse events. RESULTS: Among the 194 HCWs screened for ruling out contraindications for prophylaxis, 9 were excluded and 185 were initiated on HCQ. A total of 55 adverse events were seen in 38 (20.5%) HCWs out of which 70.9%, 29.1% were mild and moderate & none were severe. Before the completion of therapy, a total of 23 participants discontinued. Change in QTc interval on day 2 was 5 (IQR: -3.75, 11) ms and the end of week 1 was 15 ms (IQR: 2, 18). Out of the 5 HCW who turned positive for COVID-19, 2 were on HCQ. CONCLUSION: HCQ prophylaxis was found to be safe and well tolerated in HCW when administered after appropriate screening and with monitoring for adverse events.
  • |Adult[MESH]
  • |Antimalarials/administration & dosage/*adverse effects[MESH]
  • |COVID-19/*prevention & control[MESH]
  • |Contraindications, Drug[MESH]
  • |Electrocardiography[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Hydroxychloroquine/administration & dosage/*adverse effects[MESH]
  • |India[MESH]
  • |Informed Consent[MESH]
  • |Long QT Syndrome/chemically induced[MESH]
  • |Male[MESH]
  • |Mass Drug Administration/*methods[MESH]
  • |Personnel, Hospital[MESH]
  • |Preliminary Data[MESH]
  • |SARS-CoV-2[MESH]
  • |Tertiary Care Centers[MESH]


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