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10.1016/j.xcrm.2021.100245

http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100245
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suck abstract from ncbi


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pmid33778788      Cell+Rep+Med 2021 ; 2 (4): 100245
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  • A comprehensive analysis and resource to use CRISPR-Cas13 for broad-spectrum targeting of RNA viruses #MMPMID33778788
  • Lin X; Liu Y; Chemparathy A; Pande T; La Russa M; Qi LS
  • Cell Rep Med 2021[Apr]; 2 (4): 100245 PMID33778788show ga
  • The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) and variants has led to significant mortality. We recently reported that an RNA-targeting CRISPR-Cas13 system, called prophylactic antiviral CRISPR in human cells (PAC-MAN), offered an antiviral strategy against SARS-CoV-2 and influenza A virus. Here, we expand in silico analysis to use PAC-MAN to target a broad spectrum of human- or livestock-infectious RNA viruses with high specificity, coverage, and predicted efficiency. Our analysis reveals that a minimal set of 14 CRISPR RNAs (crRNAs) is able to target >90% of human-infectious viruses across 10 RNA virus families. We predict that a set of 5 experimentally validated crRNAs can target new SARS-CoV-2 variant sequences with zero mismatches. We also build an online resource (crispr-pacman.stanford.edu) to support community use of CRISPR-Cas13 for broad-spectrum RNA virus targeting. Our work provides a new bioinformatic resource for using CRISPR-Cas13 to target diverse RNA viruses to facilitate the development of CRISPR-based antivirals.
  • |COVID-19/pathology/virology[MESH]
  • |CRISPR-Cas Systems/*genetics[MESH]
  • |Humans[MESH]
  • |RNA Virus Infections/pathology/virology[MESH]
  • |RNA Viruses/*genetics/isolation & purification[MESH]
  • |RNA, Guide, CRISPR-Cas Systems/*metabolism[MESH]
  • |RNA, Viral/metabolism[MESH]
  • |SARS-CoV-2/genetics/isolation & purification[MESH]


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