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10.1016/j.xcrm.2021.100242 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2021.100242 33778787!7985929!33778787     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep+Med 2021 ; 2 (4): 100242 Nephropedia Template TP {{tp|p=33778787|t=2021. Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures |pdf=|usr=}}{{33778787}} gab.com Text Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33778787 #FOAvip Severe SARS-CoV-2 infection often leads to the development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is not clear whether ARDS from SARS-CoV-2 is similar to that observed in influenza H1N1, another common viral cause of lung injury. Here, we analyze specific ARDS regions of interest utilizing a spatial transcriptomic platform on autopsy-derived lung tissue from patients with SARS-CoV-2 (n = 3), H1N1 (n = 3), and a dual infected individual (n = 1). Enhanced gene signatures in alveolar epithelium, vascular tissue, and lung macrophages identify not only increased regional coagulopathy but also increased extracellular remodeling, alternative macrophage activation, and squamous metaplasia of type II pneumocytes in SARS-CoV-2. Both the H1N1 and dual-infected transcriptome demonstrated an enhanced antiviral response compared to SARS-CoV-2. Our results uncover regional transcriptional changes related to tissue damage/remodeling, altered cellular phenotype, and vascular injury active in SARS-CoV-2 and present therapeutic targets for COVID-19-related ARDS. Twit Text FOAVip Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=33778787 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33778787 #FOAvip English Wikipedia <ref>{{Cite pmid|33778787}}</ref> Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differential transcriptional signatures #MMPMID33778787 Margaroli C; Benson P; Sharma NS; Madison MC; Robison SW; Arora N; Ton K; Liang Y; Zhang L; Patel RP; Gaggar A Cell Rep Med 2021[Apr]; 2 (4): 100242 PMID33778787show ga Severe SARS-CoV-2 infection often leads to the development of acute respiratory distress syndrome (ARDS), with profound pulmonary patho-histological changes post-mortem. It is not clear whether ARDS from SARS-CoV-2 is similar to that observed in influenza H1N1, another common viral cause of lung injury. Here, we analyze specific ARDS regions of interest utilizing a spatial transcriptomic platform on autopsy-derived lung tissue from patients with SARS-CoV-2 (n = 3), H1N1 (n = 3), and a dual infected individual (n = 1). Enhanced gene signatures in alveolar epithelium, vascular tissue, and lung macrophages identify not only increased regional coagulopathy but also increased extracellular remodeling, alternative macrophage activation, and squamous metaplasia of type II pneumocytes in SARS-CoV-2. Both the H1N1 and dual-infected transcriptome demonstrated an enhanced antiviral response compared to SARS-CoV-2. Our results uncover regional transcriptional changes related to tissue damage/remodeling, altered cellular phenotype, and vascular injury active in SARS-CoV-2 and present therapeutic targets for COVID-19-related ARDS. |*Transcriptome[MESH] |Alveolar Epithelial Cells/metabolism/pathology[MESH] |Autopsy[MESH] |COVID-19/complications/*pathology/virology[MESH] |Humans[MESH] |Influenza A Virus, H1N1 Subtype/isolation & purification[MESH] |Influenza, Human/complications/*pathology/virology[MESH] |Lung/metabolism/*pathology[MESH] |Lymphocyte Activation[MESH] |Macrophages, Alveolar/immunology/metabolism[MESH] |Metaplasia[MESH] |Phenotype[MESH] |Respiratory Distress Syndrome/diagnosis/etiology[MESH] |SARS-CoV-2/isolation & purification[MESH]Spatial mapping of SARS-CoV-2 and H1N1 lung injury identifies differen(epmc).pdf DeepDyve Pubget Overpricing