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10.1021/acsomega.1c00157

http://scihub22266oqcxt.onion/10.1021/acsomega.1c00157
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33778286!7992141!33778286
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suck abstract from ncbi


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pmid33778286      ACS+Omega 2021 ; 6 (11): 7754-7760
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  • Ethyl Pyruvate as a Potential Defense Intervention against Cytokine Storm in COVID-19? #MMPMID33778286
  • Tanwar O; Soni A; Prajapat P; Shivhare T; Pandey P; Samaiya PK; Pandey SP; Kar P
  • ACS Omega 2021[Mar]; 6 (11): 7754-7760 PMID33778286show ga
  • COVID-19 is a deadly pandemic and has resulted in a huge loss of money and life in the past few months. It is well known that the SARS-CoV-2 gene mutates relatively slowly as compared to other viruses but still may create hurdles in developing vaccines. Therefore, there is a need to develop alternative routes for its management and treatment of COVID-19. Based on the severity of viral infection in COVID-19 patients, critically ill patients ( approximately 5%, with old age, and comorbidities) are at high risk of morbidities. The reason for this severity in such patients is attributed to "misleading cytokine storm", which produces ARDS and results in the deaths of critically ill patients. In this connection, ethyl pyruvate (EP) controls these cytokines/chemokines, is an anti-inflammatory agent, and possesses a protective effect on the lungs, brain, heart, and mitochondria against various injuries. Considering these facts, we propose that the site-selective EP formulations (especially aerosols) could be the ultimate adjuvant therapy for the regulation of misleading cytokine storm in severely affected COVID-19 patients and could reduce the mortalities.
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