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10.1016/j.anpede.2020.12.011

http://scihub22266oqcxt.onion/10.1016/j.anpede.2020.12.011
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suck abstract from ncbi


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pmid33778108      An+Pediatr+(Engl+Ed) 2021 ; 94 (5): 318-326
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  • Differential clinic in children infected by SARS-CoV-2, traceability of contacts and cost-effectiveness of diagnostic tests: Cross-sectional observational study #MMPMID33778108
  • Fiel-Ozores A; Gonzalez-Duran ML; Novoa-Carballal R; Portugues-de la Red MDM; Fernandez-Pinilla I; Cabrera-Alvargonzalez JJ; Martinez-Reglero C; Rey-Cao S; Concheiro-Guisan A
  • An Pediatr (Engl Ed) 2021[May]; 94 (5): 318-326 PMID33778108show ga
  • INTRODUCTION: Given the possible coexistence of infection by the SARS-CoV-2 with other seasonal infections, the aim is to identify differential symptoms. The role of children in intrafamily contagion and the sensitivity of reverse transcriptase polymerase chain reaction (RT-PCR) in an area with low community transmission has been studied. MATERIAL AND METHODS: Cross-sectional observational study. Patients between 0-15 years studied by RT-PCR technique due to clinical suspicion of infection by SARS-CoV-2 virus in the months of March-May 2020. Survey on symptoms and contacts. Determination of Anti-SARS-CoV-2 antibodies at least 21 days after the RT-PCR test. RESULTS: 126 patients were included, 33 with confirmed infection and age mean 8.4 years (95% CI 6.8-10.5) higher than not infected. Fever was the most common and with greater sensitivity. The differences found were a greater frequency of anosmia (P = .029) and headache (P = .009) among children infected with a specificity of 96.7% and 81.5% respectively. There were no differences in the duration of the symptoms. 81.8% of those infected were probably infected in the nucleus 85.2% by a parent who worked outside the home. The sensitivity of RT-PCR was 70.9% and its negative predictive value 91.1%. CONCLUSIONS: The clinical picture is nonspecific and the symptoms more specific difficult to detect in younger children. Children had a reduced role in the intrafamily transmission. The sensitivity of RT-PCR could be related to a less contagiousness in children after one week of infection.
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