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10.3389/fmed.2021.629112

http://scihub22266oqcxt.onion/10.3389/fmed.2021.629112
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33777976!7994262!33777976
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suck abstract from ncbi


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pmid33777976      Front+Med+(Lausanne) 2021 ; 8 (ä): 629112
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  • Case Report: A Severe SARS-CoV-2 Infection in a Teenager With Angelman Syndrome #MMPMID33777976
  • Lopes AGD; Celestino CSH; Barros TTA; Fevereiro AG; Gejer DH; Oliveira FMF; Brasil JM; Bossolan RM; Pinto GCC; Santos ACEZ; Divan LA; Alves IAB; Oliveira DBL; Machado RRG; Thomazelli LM; Hiyane MI; Brelaz-Abreu L; Braganca-Jardim E; Heinen LBS; Barrientos ACM; Mau LB; Camara NOS; Bueno DF; Amano MT
  • Front Med (Lausanne) 2021[]; 8 (ä): 629112 PMID33777976show ga
  • Teenagers generally present mild to no symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In the present report, we present the case of a 14-year-old boy with Angelman syndrome (AS) who presented with severe COVID-19 symptoms. He spent 20 days in the ICU with elevated inflammatory biomarkers (C-reactive protein and D-dimer) and increased peaks of neutrophil-to-lymphocyte ratio, which is uncommon for teenagers diagnosed with COVID-19. Although he showed physiological instability, he was able to produce neutralizing antibodies, suggesting a functional immune response. The literature concerning the immune response to infections in patients with AS is still poor, and to our knowledge, this was the first report of a patient with AS diagnosed with COVID-19. As such, the present study may alert other patients with AS or other rare diseases that they lack a competent immune response and could suffer severe consequences of SARS-CoV-2 infection.
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