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10.3389/fcimb.2021.632490 http://scihub22266oqcxt.onion/10.3389/fcimb.2021.632490 33777844!7991797!33777844     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Cell+Infect+Microbiol 2021 ; 11 (ä): 632490 Nephropedia Template TP {{tp|p=33777844|t=2021. Next-Generation Sequencing Reveals the Progression of COVID-19 |pdf=|usr=}}{{33777844}} gab.com Text Next-Generation Sequencing Reveals the Progression of COVID-19 JO: Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33777844 #FOAvip The novel coronavirus SARS-CoV-2 (causing the disease COVID-19) has caused a highly transmissible and ongoing pandemic worldwide. Due to its rapid development, next-generation sequencing plays vital roles in many aspects. Here, we summarize the current knowledge on the origin and human transmission of SARS-CoV-2 based on NGS analysis. The ACE2 expression levels in various human tissues and relevant cells were compared to provide insights into the mechanism of SAS-CoV-2 infection. Gut microbiota dysbiosis observed by metagenome sequencing and the immunogenetics of COVID-19 patients according to single-cell sequencing analysis were also highlighted. Overall, the application of these sequencing techniques could be meaningful for finding novel intermediate SARS-CoV-2 hosts to block interspecies transmission. This information will further benefit SARS-CoV-2 diagnostic development and new therapeutic target discovery. The extensive application of NGS will provide powerful support for our fight against future public health emergencies. Twit Text FOAVip Next-Generation Sequencing Reveals the Progression of COVID-19 ????Front Cell Infect Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=33777844 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33777844 #FOAvip English Wikipedia <ref>{{Cite pmid|33777844}}</ref> Next-Generation Sequencing Reveals the Progression of COVID-19 #MMPMID33777844 Chen X; Kang Y; Luo J; Pang K; Xu X; Wu J; Li X; Jin S Front Cell Infect Microbiol 2021[]; 11 (ä): 632490 PMID33777844show ga The novel coronavirus SARS-CoV-2 (causing the disease COVID-19) has caused a highly transmissible and ongoing pandemic worldwide. Due to its rapid development, next-generation sequencing plays vital roles in many aspects. Here, we summarize the current knowledge on the origin and human transmission of SARS-CoV-2 based on NGS analysis. The ACE2 expression levels in various human tissues and relevant cells were compared to provide insights into the mechanism of SAS-CoV-2 infection. Gut microbiota dysbiosis observed by metagenome sequencing and the immunogenetics of COVID-19 patients according to single-cell sequencing analysis were also highlighted. Overall, the application of these sequencing techniques could be meaningful for finding novel intermediate SARS-CoV-2 hosts to block interspecies transmission. This information will further benefit SARS-CoV-2 diagnostic development and new therapeutic target discovery. The extensive application of NGS will provide powerful support for our fight against future public health emergencies. |Angiotensin-Converting Enzyme 2/genetics/metabolism[MESH] |COVID-19/*epidemiology/microbiology/transmission/virology[MESH] |Dysbiosis/virology[MESH] |Gastrointestinal Microbiome[MESH] |High-Throughput Nucleotide Sequencing/*methods[MESH] |Humans[MESH] |Metagenome[MESH] |Pandemics[MESH]Next-Generation Sequencing Reveals the Progression of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing