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10.1016/j.rmcr.2021.101397

http://scihub22266oqcxt.onion/10.1016/j.rmcr.2021.101397
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suck abstract from ncbi


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pmid33777690      Respir+Med+Case+Rep 2021 ; 33 (ä): 101397
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  • Therapeutic approach for severe COVID-19 and immunocompromised patients A case series #MMPMID33777690
  • Simioli F; Martino M; Annunziata A; Carannante N; Fiorentino G
  • Respir Med Case Rep 2021[]; 33 (ä): 101397 PMID33777690show ga
  • BACKGROUND: COVID-19 is a potentially critical infectious disease. Inflammatory response and disease severity may vary according to immune system status. The aim of this case series is to investigate different presentation of COVID-19 in immunocompromised patients. METHODS: this is a single centre case series about 17 immunocompromised patients admitted to our respiratory department during the recent COVID-19 pandemic. White blood cell count, C reactive protein, interleukin 6, lymphocytic subpopulation count (CD4(+), CD8(+), CD20(+)) and immunoglobulin count (IgG, IgM, IgA) were measured at hospitalization. RESULTS: the most common causes of immunosuppression observed in our severe COVID-19 population are hematological malignancies, immunosuppressant drugs for transplant, primary immunodeficiency and inflammatory bowel disease. Onset symptoms were fever (88%), cough (53%), dyspnoea (24%), asthenia (35%), anosmia and/or ageusia (17%), expectoration (12%). Compared to benign conditions, patients with malignancies show a lower lymphocytic count (490 vs 1100 cells/uL) and higher interleukin 6 (33 vs 13 pg/mL). CONCLUSIONS: immunocompromised patients are at risk of adverse outcome from COVID-19. Hematological malignancies and anti-CD20 therapies induce a high risk. Primary immunodeficiency and classical immunosuppressant such as calcineurin inhibitors and antimetabolites share an intermediate risk.
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