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10.3389/fimmu.2021.657711

http://scihub22266oqcxt.onion/10.3389/fimmu.2021.657711
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33777055!7994748!33777055
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suck abstract from ncbi


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pmid33777055      Front+Immunol 2021 ; 12 (ä): 657711
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  • Mini Review Immunological Consequences of Immunization With COVID-19 mRNA Vaccines: Preliminary Results #MMPMID33777055
  • Lombardi A; Bozzi G; Ungaro R; Villa S; Castelli V; Mangioni D; Muscatello A; Gori A; Bandera A
  • Front Immunol 2021[]; 12 (ä): 657711 PMID33777055show ga
  • Background: BNT162b2 and mRNA-1273 are the two recently approved mRNA-based vaccines against COVID-19 which has shown excellent safety and efficacy. Preliminary data about specific and neutralizing antibodies is available covering the first 100 days after vaccination. Methods: We reviewed all the publications regarding the immunologic consequences of BNT162b2 and mRNA-1273 vaccination. A summary of specific antibodies concentration and neutralizing antibodies titers elicited by each vaccine is provided. Results: BNT162b2 and mRNA-1273 displayed a reassuring safety and efficacy profile, with the latter above 94%. They can elicit specific antibodies titers and neutralizing antibodies concentrations that are far superior from those observed among COVID-19 human convalescent serum, across a wide span of age, for at least 100 days after vaccination. Moreover, the vaccine-induced T cellular response is oriented toward a T(H)1 response and no evidence of vaccine-enhanced disease have been reported. Discussion: BNT162b2 and mRNA-1273 can elicit specific antibodies titers and neutralizing antibodies concentrations above those observed among COVID-19 human convalescent serum in the first 100 days after vaccination. Data about vaccine efficacy in those with previous COVID-19 or immunocompromised is still limited.
  • |*Immunization[MESH]
  • |*Immunogenicity, Vaccine[MESH]
  • |2019-nCoV Vaccine mRNA-1273[MESH]
  • |Animals[MESH]
  • |Antibodies, Neutralizing/blood[MESH]
  • |Antibodies, Viral/blood[MESH]
  • |BNT162 Vaccine[MESH]
  • |COVID-19 Vaccines/adverse effects/*therapeutic use[MESH]
  • |COVID-19/blood/immunology/*prevention & control/virology[MESH]
  • |Diffusion of Innovation[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |SARS-CoV-2/genetics/*immunology[MESH]
  • |Treatment Outcome[MESH]
  • |Vaccines, Synthetic/adverse effects/*therapeutic use[MESH]


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